Unravelling the structural and mechanistic basis of CRISPR–Cas systems
Bacteria and archaea have evolved sophisticated adaptive immune systems, known as
CRISPR–Cas (clustered regularly interspaced short palindromic repeats–CRISPR …
CRISPR–Cas (clustered regularly interspaced short palindromic repeats–CRISPR …
CRISPR-mediated adaptive immune systems in bacteria and archaea
R Sorek, CM Lawrence… - Annual review of …, 2013 - annualreviews.org
Effective clearance of an infection requires that the immune system rapidly detects and
neutralizes invading parasites while strictly avoiding self-antigens that would result in …
neutralizes invading parasites while strictly avoiding self-antigens that would result in …
Protospacer recognition motifs: mixed identities and functional diversity
Protospacer adjacent motifs (PAMs) were originally characterized for CRISPR-Cas systems
that were classified on the basis of their CRISPR repeat sequences. A few short 2–5 bp …
that were classified on the basis of their CRISPR repeat sequences. A few short 2–5 bp …
Cytotoxic chromosomal targeting by CRISPR/Cas systems can reshape bacterial genomes and expel or remodel pathogenicity islands
RB Vercoe, JT Chang, RL Dy, C Taylor… - PLoS …, 2013 - journals.plos.org
In prokaryotes, clustered regularly interspaced short palindromic repeats (CRISPRs) and
their associated (Cas) proteins constitute a defence system against bacteriophages and …
their associated (Cas) proteins constitute a defence system against bacteriophages and …
Bipartite recognition of target RNAs activates DNA cleavage by the Type III-B CRISPR–Cas system
JR Elmore, NF Sheppard, N Ramia… - Genes & …, 2016 - genesdev.cshlp.org
CRISPR–Cas systems eliminate nucleic acid invaders in bacteria and archaea. The effector
complex of the Type III-B Cmr system cleaves invader RNAs recognized by the CRISPR …
complex of the Type III-B Cmr system cleaves invader RNAs recognized by the CRISPR …
Evolutionary and mechanistic diversity of Type IF CRISPR-associated transposons
Canonical CRISPR-Cas systems utilize RNA-guided nucleases for targeted cleavage of
foreign nucleic acids, whereas some nuclease-deficient CRISPR-Cas complexes have been …
foreign nucleic acids, whereas some nuclease-deficient CRISPR-Cas complexes have been …
Type IE CRISPR-cas systems discriminate target from non-target DNA through base pairing-independent PAM recognition
ER Westra, E Semenova, KA Datsenko… - PLoS …, 2013 - journals.plos.org
Discriminating self and non-self is a universal requirement of immune systems. Adaptive
immune systems in prokaryotes are centered around repetitive loci called CRISPRs …
immune systems in prokaryotes are centered around repetitive loci called CRISPRs …
Priming in the Type IF CRISPR-Cas system triggers strand-independent spacer acquisition, bi-directionally from the primed protospacer
C Richter, RL Dy, RE McKenzie… - Nucleic acids …, 2014 - academic.oup.com
Clustered regularly interspaced short palindromic repeats (CRISPR), in combination with
CRISPR associated (cas) genes, constitute CRISPR-Cas bacterial adaptive immune …
CRISPR associated (cas) genes, constitute CRISPR-Cas bacterial adaptive immune …
Mechanism for Cas4-assisted directional spacer acquisition in CRISPR–Cas
Prokaryotes adapt to challenges from mobile genetic elements by integrating spacers
derived from foreign DNA in the CRISPR array. Spacer insertion is carried out by the Cas1 …
derived from foreign DNA in the CRISPR array. Spacer insertion is carried out by the Cas1 …
Method of modulating cell resistance
R Barrangou, P Boyaval, C Fremaux… - US Patent …, 2018 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
37692491&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
37692491&utm_source= google_patent&utm_medium= platform_link&utm_campaign …