The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity

Y Xiong, BB Mi, Z Lin, YQ Hu, L Yu, KK Zha… - Military Medical …, 2022 - Springer
Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting
a variety of cell types, whose activity and interplay must be precisely mediated for effective …

Novel trends in hydrogel development for biomedical applications: A review

P Sánchez-Cid, M Jiménez-Rosado, A Romero… - Polymers, 2022 - mdpi.com
Nowadays, there are still numerous challenges for well-known biomedical applications,
such as tissue engineering (TE), wound healing and controlled drug delivery, which must be …

Biofilm Microenvironment‐Responsive Self‐Assembly Nanoreactors for All‐Stage Biofilm Associated Infection through Bacterial Cuproptosis‐like Death and …

J Mei, D Xu, L Wang, L Kong, Q Liu, Q Li… - Advanced …, 2023 - Wiley Online Library
Bacterial biofilm‐associated infections (BAIs) are the leading cause of prosthetic implant
failure. The dense biofilm structure prevents antibiotic penetration, while the highly acidic …

Immunomodulatory hydrogels: advanced regenerative tools for diabetic foot ulcer

Y Xiong, Q Feng, L Lu, K Zha, T Yu, Z Lin… - Advanced Functional …, 2023 - Wiley Online Library
Diabetic foot ulcer (DFU) is one of the most common complications of diabetes, bringing
physical and mental challenges for patients due to the lack of efficient curative therapy …

Multifunctional PtCuTe nanosheets with strong ROS scavenging and ROS‐independent antibacterial properties promote diabetic wound healing

Y Guo, S Ding, C Shang, C Zhang, M Li… - Advanced …, 2024 - Wiley Online Library
Nanozymes, as one of the most efficient reactive oxygen species (ROS)‐scavenging
biomaterials, are receiving wide attention in promoting diabetic wound healing. Despite …

New injectable chitosan-hyaluronic acid based hydrogels for hemostasis and wound healing

H Weng, W Jia, M Li, Z Chen - Carbohydrate polymers, 2022 - Elsevier
It is a challenge to develop hemostatic and wound dressings that are used for irregular
shape and deep wound. Herein, a series of novel N-succinyl chitosan-oxidized hyaluronic …

Photopolymerizable, immunomodulatory hydrogels of gelatin methacryloyl and carboxymethyl chitosan as all-in-one strategic dressing for wound healing

S Ding, S He, K Ye, X Shao, Q Yang, G Yang - International Journal of …, 2023 - Elsevier
Microenvironment regeneration in wound tissue is crucial for wound healing. However,
achieving desirable wound microenvironment regeneration involves multiple stages …

Spatiotemporal On–Off Immunomodulatory Hydrogel Targeting NLRP3 Inflammasome for the Treatment of Biofilm‐Infected Diabetic Wounds

J Zhou, J Mei, Q Liu, D Xu, X Wang… - Advanced Functional …, 2023 - Wiley Online Library
Biofilm‐infected diabetic wounds (BIDWs) with hyperglycemia and bacterial colonization are
characterized by disordered inflammation and abnormal activation of NLRP3 …

Rational design of bioactive materials for bone hemostasis and defect repair

Y Gai, Y Yin, L Guan, S Zhang, J Chen… - Cyborg and Bionic …, 2023 - spj.science.org
Everyday unnatural events such as trauma, accidents, military conflict, disasters, and even
medical malpractice create open wounds and massive blood loss, which can be life …

Immunomodulatory nanosystems: advanced delivery tools for treating chronic wounds

X Chu, Y Xiong, S Knoedler, L Lu, AC Panayi… - Research, 2023 - spj.science.org
The increasingly aging society led to a rise in the prevalence of chronic wounds (CWs),
posing a significant burden to public health on a global scale. One of the key features of …