Abstract Peptidylarginine deiminase 4 (PADI4), a new histone modification enzyme, which
converts both arginine and monomethyl-arginine to citrulline, has gained massive attention …

Around 50% of rheumatoid arthritis (RA) patients show some extra-articular manifestation,
with the lung a usually affected organ; in addition, the presence of anti-citrullinated protein …

Rheumatoid arthritis (RA) is the most common rheumatic autoimmune disease worldwide,
which causes progressive joint damage and can lead to functional disability. Despite …

Background Rheumatoid arthritis (RA) is an inflammatory debilitating disease that affects the
joints in the early and productive phases of an individual's life. Several cytokines have been …

Antibodies against cyclic citrullinated peptides (anti-CCP) are widely used for diagnosis of
rheumatoid arthritis (RA). We performed a comparative analysis of antibodies targeting the …

Background Anti-citrullinated-peptide antibodies (ACPA) have been detected in individuals
with developing rheumatoid arthritis (RA) before the onset of symptom, with an initially …

Aim We sought to investigate the release of neutrophil extracellular traps (NETs) in
neutrophils from individuals with rheumatoid arthritis (RA) and controls and compare the …

Circular RNAs (circRNAs) are regarded as pivotal regulators in bone metabolism. However,
the role of circRNAs in osteoblast mineralization remains largely unknown. Herein, we …

Citrullination is catalyzed by the peptidyl arginine deiminase 4 (PAD4) enzyme, encoded by
the PADI4 gene. Increased PAD4 activity promotes the onset and progression of rheumatoid …

Background Peptidyl arginine deiminase 4 (PADI4) has been implicated in Rheumatoid
arthritis (RA) pathogenesis. Here we aimed to evaluate the association of PADI4 gene …