Cancer development is driven by the accumulation of alterations affecting the structure and
function of the genome. Whereas genetic changes disrupt the DNA sequence, epigenetic …

Abstract Context The European Association of Urology (EAU) has released an updated
version of the guidelines on non–muscle-invasive bladder cancer (NMIBC). Objective To …

Carcinogenesis is accompanied by widespread DNA methylation changes within the cell.
These changes are characterized by a globally hypomethylated genome with focal …

BACKGROUND Current methods for the detection and surveillance of bladder cancer (BCa)
are often invasive and/or possess suboptimal sensitivity and specificity, especially in early …

Background and objective This publication represents a summary of the updated 2024
European Association of Urology (EAU) guidelines for non–muscle-invasive bladder cancer …

The increase in recent scientific studies on cancer biomarkers has brought great new
insights into the field. Moreover, novel technological breakthroughs such as long read …

Context During the past decade, several urinary biomarker tests (UBTs) for bladder cancer
have been developed and made commercially available. However, none of these is …

Diagnosing, selecting therapy for, and monitoring cancer in patients using a minimally
invasive blood test represents a significant advance in precision medicine. Wide variability …

Bladder cancer (BC) is characterized by high incidence and recurrence rates together with
genomic instability and elevated mutation degree. Currently, cystoscopy combined with …

Recently, there has been a great effort to develop tests based on non-invasive urinary
biomarkers (NMIBCs). These tests are based on the fact that NMIBCs are heterogeneous at …