Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases
KM Wagner, CB McReynolds, WK Schmidt… - Pharmacology & …, 2017 - Elsevier
Eicosanoids are biologically active lipid signaling molecules derived from polyunsaturated
fatty acids. Many of the actions of eicosanoid metabolites formed by cyclooxygenase and …
fatty acids. Many of the actions of eicosanoid metabolites formed by cyclooxygenase and …
Inflammatory bowel disease: etiology and pathogenesis
C Fiocchi - Gastroenterology, 1998 - Elsevier
Inflammatory bowel disease: Etiology and pathogenesis - ScienceDirect Skip to main contentSkip
to article Elsevier logo Journals & Books Search RegisterSign in View PDF Download full issue …
to article Elsevier logo Journals & Books Search RegisterSign in View PDF Download full issue …
Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis
TD Warner, F Giuliano, I Vojnovic… - Proceedings of the …, 1999 - National Acad Sciences
The beneficial actions of nonsteroid anti-inflammatory drugs (NSAID) can be associated with
inhibition of cyclo-oxygenase (COX)-2 whereas their harmful side effects are associated with …
inhibition of cyclo-oxygenase (COX)-2 whereas their harmful side effects are associated with …
The coxibs, selective inhibitors of cyclooxygenase-2
GA FitzGerald, C Patrono - New England Journal of Medicine, 2001 - Mass Medical Soc
Nonsteroidal antiinflammatory drugs (NSAIDs) are widely used to treat arthritis, menstrual
pain, and headache. Although they are effective, their long-term use is limited by …
pain, and headache. Although they are effective, their long-term use is limited by …
Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2
RA Gupta, RN DuBois - Nature Reviews Cancer, 2001 - nature.com
Population-based studies have established that long-term intake of non-steroidal anti-
inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of …
inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of …
Copper complexes of non-steroidal anti-inflammatory drugs: an opportunity yet to be realized
JE Weder, CT Dillon, TW Hambley, BJ Kennedy… - Coordination Chemistry …, 2002 - Elsevier
The proposed curative properties of Cu-based non-steroidal anti-inflammatory drugs
(NSAIDs) have led to the development of numerous Cu (II) complexes of NSAIDs with …
(NSAIDs) have led to the development of numerous Cu (II) complexes of NSAIDs with …
Organotypic 3D cell culture models: using the rotating wall vessel to study host–pathogen interactions
J Barrila, AL Radtke, A Crabbé, SF Sarker… - Nature Reviews …, 2010 - nature.com
Appropriately simulating the three-dimensional (3D) environment in which tissues normally
develop and function is crucial for engineering in vitro models that can be used for the …
develop and function is crucial for engineering in vitro models that can be used for the …
The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut
K Kabashima, T Saji, T Murata… - The Journal of …, 2002 - Am Soc Clin Investig
We used mice deficient in each of the eight types and subtypes of prostanoid receptors and
examined the roles of prostanoids in dextran sodium sulfate–induced (DSS-induced) colitis …
examined the roles of prostanoids in dextran sodium sulfate–induced (DSS-induced) colitis …
Myofibroblasts. II. Intestinal subepithelial myofibroblasts
DW Powell, RC Mifflin, JD Valentich… - … of Physiology-Cell …, 1999 - journals.physiology.org
Intestinal subepithelial myofibroblasts (ISEMF) and the interstitial cells of Cajal are the two
types of myofibroblasts identified in the intestine. Intestinal myofibroblasts are activated and …
types of myofibroblasts identified in the intestine. Intestinal myofibroblasts are activated and …
Recent advancement in the discovery and development of COX-2 inhibitors: Insight into biological activities and SAR studies (2008–2019)
Cyclooxygenase-2 is a very important physiological enzyme playing key roles in various
biological functions especially in the mechanism of pain and inflammation, among other …
biological functions especially in the mechanism of pain and inflammation, among other …