The uptake and metabolism of nutrients support fundamental cellular process from
bioenergetics to biomass production and cell fate regulation. While many studies of cell …

Few metabolites can claim a more central and versatile role in cell metabolism than acetyl
coenzyme A (acetyl-CoA). Acetyl-CoA is produced during nutrient catabolism to fuel the …

Mitochondria are signaling organelles that regulate a wide variety of cellular functions and
can dictate cell fate. Multiple mechanisms contribute to communicate mitochondrial fitness to …

Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …

Consumption of fructose has risen markedly in recent decades owing to the use of sucrose
and high-fructose corn syrup in beverages and processed foods, and this has contributed to …

Acetyl-CoA carboxylases (ACCs) are enzymes that catalyze the carboxylation of acetyl-CoA
to produce malonyl-CoA. In mammals, ACC1 and ACC2 are two members of ACCs. ACC1 …

Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

Mitochondria are intracellular organelles involved in energy production, cell metabolism and
cell signaling. They are essential not only in the process of ATP synthesis, lipid metabolism …

Elevated production of collagen-rich extracellular matrix is a hallmark of cancer-associated
fibroblasts (CAFs) and a central driver of cancer aggressiveness. Here we find that proline, a …

Glioblastoma (GBM) is a primary tumor of the brain defined by its uniform lethality and
resistance to conventional therapies. There have been considerable efforts to untangle the …