Objective The purpose of this study was to identify a panel of biomarkers for distinguishing
early stage sepsis patients from non-infected trauma patients. Background Accurate …

The assembly of the mammalian brain is orchestrated by temporally coordinated waves of
gene expression. Post-transcriptional regulation by microRNAs (miRNAs) is a key aspect of …

Spinal motor neurons (MNs) represent a highly vulnerable cellular population, which is
affected in fatal neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) …

Integrins are a family of 24 different heterodimers that are indispensable for multicellular life.
Cell polarity, adhesion and migration are controlled by integrins delivered to the cell surface …

Neurons critically depend on regulated RNA localization and tight control of spatiotemporal
gene expression to maintain their morphological and functional integrity. Mutations in the …

Objective The consequences of mutations in genes associated with monogenic forms of
diabetes on human pancreas development cannot be studied in a time-resolved fashion in …

Introduction The molecular programs regulating human pancreatic endocrine cell induction
and fate allocation are not well deciphered. Here, we investigated the spatiotemporal …

Background Peritoneal metastasis of gastric cancer is closely associated with dismal
prognosis. In previous preclinical proof-of-concept studies, an amido-bridged nucleic acid …

Pancreatic β-cells in the islets of Langerhans are key to maintaining glucose homeostasis by
secreting the peptide hormone insulin. Insulin is packaged within vesicles named insulin …

Genes with cell type specific expression typically encode for proteins that have cell type
specific functions. Single cell RNAseq (scRNAseq) has facilitated the identification of such …