Rationally seeded computational protein design of ɑ-helical barrels

KI Albanese, R Petrenas, F Pirro, EA Naudin… - Nature Chemical …, 2024 - nature.com
Computational protein design is advancing rapidly. Here we describe efficient routes starting
from validated parallel and antiparallel peptide assemblies to design two families of α …

Oral tolerance to systemic vaccination remains intact without RORγt expression in regulatory T cells

NB Potchen, AMF Johnson, K Hager, J Graham, P Van… - Iscience, 2023 - cell.com
Many promising vaccine candidates and licensed vaccines lead to variable immune
responses within humans. Studies suggest that environmental exposures in the …