The role of oxytocin, vasopressin, and their receptors at nociceptors in peripheral pain modulation

H Zheng, JY Lim, Y Kim, ST Jung, SW Hwang - Frontiers in …, 2021 - Elsevier
Oxytocin and vasopressin are neurohypophyseal hormones with sequence similarity and
play a central role in bodily homeostatic regulation. Pain is currently understood to be an …

Comparing vasopressin and oxytocin fiber and receptor density patterns in the social behavior neural network: Implications for cross-system signaling

CJW Smith, BT DiBenedictis, AH Veenema - Frontiers in …, 2019 - Elsevier
Vasopressin (AVP) and oxytocin (OXT) regulate social behavior by binding to their canonical
receptors, the vasopressin V1a receptor (V1aR) and oxytocin receptor (OTR), respectively …

Up‐regulation of oxytocin receptors on peripheral sensory neurons mediates analgesia in chemotherapy‐induced neuropathic pain

L Li, P Li, J Guo, Y Wu, Q Zeng, N Li… - British Journal of …, 2023 - Wiley Online Library
Background and Purpose Chemotherapy‐induced neuropathic pain (CINP) currently has
limited effective treatment. Although the roles of oxytocin (OXT) and the oxytocin receptor …

[HTML][HTML] Chemogenetic Activation of Oxytocin Neurons Improves Pain in a Reserpine-induced Fibromyalgia Rat Model

N Ikeda, M Kawasaki, K Baba, H Nishimura, T Fujitani… - Neuroscience, 2023 - Elsevier
Fibromyalgia (FM) is a syndrome characterized by chronic pain with depression as a
frequent comorbidity. However, efficient management of the pain and depressive symptoms …

Oxytocin-dependent regulation of TRPs expression in trigeminal ganglion neurons attenuates orofacial neuropathic pain following infraorbital nerve injury in rats

M Ando, Y Hayashi, S Hitomi, I Shibuta… - International journal of …, 2020 - mdpi.com
We evaluated the mechanisms underlying the oxytocin (OXT)-induced analgesic effect on
orofacial neuropathic pain following infraorbital nerve injury (IONI). IONI was established …

Systematic review: pain, cognition, and cardioprotection—unpacking oxytocin's contributions in a sport context

P Szabó, S Bonet, R Hetényi, D Hanna… - Frontiers in …, 2024 - frontiersin.org
Introduction This systematic review investigates the interplay between oxytocin and
exercise; in terms of analgesic, anti-inflammatory, pro-regenerative, and cardioprotective …

Hypothalamic Paraventricular Stimulation Inhibits Nociceptive Wide Dynamic Range Trigeminocervical Complex Cells via Oxytocinergic Transmission

M Condés-Lara, G Martínez-Lorenzana… - Journal of …, 2024 - Soc Neuroscience
Oxytocinergic transmission blocks nociception at the peripheral, spinal, and supraspinal
levels through the oxytocin receptor (OTR). Indeed, a neuronal pathway from the …

Upregulation of the hypothalamo-neurohypophysial system and activation of vasopressin neurones attenuates hyperalgesia in a neuropathic pain model rat

K Baba, M Kawasaki, H Nishimura, H Suzuki… - Scientific Reports, 2022 - nature.com
Arginine vasopressin (AVP) is a hypothalamic neurosecretory hormone well known as an
antidiuretic, and recently reported to be involved in pain modulation. The expression kinetics …

Oxytocin, GABA, and TRPV1, the analgesic triad?

A Gonzalez-Hernandez, A Charlet - Frontiers in Molecular …, 2018 - frontiersin.org
The hypothalamic non-apeptide oxytocin (OT) has several physiological functions, ranging
from lactation to social attachment (Gimpl and Fahrenholz, 2001). More recently, a collection …

The glial cell's role in antinociceptive differential effects of oxytocin upon female and male rats

AB Salinas‐Abarca, FG Vázquez‐Cuevas… - … Journal of Pain, 2022 - Wiley Online Library
Background Sex plays a crucial role in pain processing and response to analgesic drugs.
Indeed, spinal glia seems to be significant in the sexual dimorphism observed in the above …