Mechanism of interferon alpha therapy for chronic hepatitis B and potential approaches to improve its therapeutic efficacy
Hepatitis B virus (HBV) chronically infects 296 million people worldwide and causes more
than 820,000 deaths annually due to cirrhosis and hepatocellular carcinoma. Current …
than 820,000 deaths annually due to cirrhosis and hepatocellular carcinoma. Current …
[PDF][PDF] Present and future therapies of hepatitis B: from discovery to cure
Hepatitis B virus (HBV) is a significant global pathogen, infecting more than 240 million
people worldwide. While treatment for HBV has improved, HBV patients often require …
people worldwide. While treatment for HBV has improved, HBV patients often require …
[HTML][HTML] Combination of tenofovir disoproxil fumarate and peginterferon α-2a increases loss of hepatitis B surface antigen in patients with chronic hepatitis B
P Marcellin, SH Ahn, X Ma, FA Caruntu, WY Tak… - Gastroenterology, 2016 - Elsevier
Background & Aims Patients chronically infected with the hepatitis B virus rarely achieve
loss of serum hepatitis B surface antigen (HBsAg) with the standard of care. We evaluated …
loss of serum hepatitis B surface antigen (HBsAg) with the standard of care. We evaluated …
Interferon-γ and tumor necrosis factor-α produced by T cells reduce the HBV persistence form, cccDNA, without cytolysis
Y Xia, D Stadler, J Lucifora, F Reisinger, D Webb… - Gastroenterology, 2016 - Elsevier
Background & Aims Viral clearance involves immune cell cytolysis of infected cells.
However, studies of hepatitis B virus (HBV) infection in chimpanzees have indicated that …
However, studies of hepatitis B virus (HBV) infection in chimpanzees have indicated that …
IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome
L Belloni, L Allweiss, F Guerrieri… - The Journal of …, 2012 - Am Soc Clin Investig
HBV infection remains a leading cause of death worldwide. IFN-α inhibits viral replication in
vitro and in vivo, and pegylated IFN-α is a commonly administered treatment for individuals …
vitro and in vivo, and pegylated IFN-α is a commonly administered treatment for individuals …
Chronic hepatitis B: virology, natural history, current management and a glimpse at future opportunities
The host immune system plays an important role in chronic hepatitis B (CHB), both in viral
clearance and hepatocellular damage. Advances in our understanding of the natural history …
clearance and hepatocellular damage. Advances in our understanding of the natural history …
The role of cccDNA in HBV maintenance
L Allweiss, M Dandri - Viruses, 2017 - mdpi.com
Chronic hepatitis B virus (HBV) infection continues to be a major health burden worldwide; it
can cause various degrees of liver damage and is strongly associated with the development …
can cause various degrees of liver damage and is strongly associated with the development …
Interferon and interferon-stimulated genes in HBV treatment
Q Li, B Sun, Y Zhuo, Z Jiang, R Li, C Lin, Y Jin… - Frontiers in …, 2022 - frontiersin.org
Human hepatitis B virus (HBV) is a small enveloped DNA virus with a complex life cycle. It is
the causative agent of acute and chronic hepatitis. HBV can resist immune system …
the causative agent of acute and chronic hepatitis. HBV can resist immune system …
New insight in the pathobiology of hepatitis B virus infection
M Dandri, S Locarnini - Gut, 2012 - gut.bmj.com
Chronic hepatitis B virus (HBV) infection remains a major health burden and the main risk
factor for the development of hepatocellular carcinoma worldwide. However, HBV is not …
factor for the development of hepatocellular carcinoma worldwide. However, HBV is not …