In the early 2000s, caspase-1, an important molecule that has been shown to be involved in
the regulation of inflammation, cell survival and diseases, was given a new function …

The innate immune system comprises several classes of pattern recognition receptors,
including Toll-like receptors (TLRs), NOD-like receptors (NLRs), and RIG-1-like receptors …

Fifteen years have passed since the cloning and characterization of the interleukin-1β-
converting enzyme (ICE/caspase-1), the first identified member of a family of proteases …

The NOD-like receptors have important roles in innate immunity as intracellular sensors of
microbial components and cell injury. It has been proposed that these cytosolic proteins …

Abstract Caspase-4/5 in humans and caspase-11 in mice bind hexa-acylated lipid A, the
lipid moeity of lipopolysaccharide (LPS), to induce the activation of non-canonical …

LPS stimulates monocytes/macrophages through the activation of signaling events that
modulate the production of inflammatory cytokines. Apigenin, a flavonoid abundantly found …

The innate immune system is critical in recognizing bacterial and viral infections to evoke a
proper immune response. Certain members of the intracellular nucleotide‐binding and …

Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that plays an important role in host
defense and inflammatory diseases. The maturation and secretion of IL-1β are mediated by …

Francisella tularensis is a highly infectious gram-negative coccobacillus that causes the
zoonosis tularemia. This bacterial pathogen causes a plague-like disease in humans after …

Caspase-1 activation is a central event in innate immune responses to many pathogenic
infections and tissue damage. The NLRP3 inflammasome, a multiprotein scaffolding …