The role of pro-Inflammatory cytokines in the pathogenesis of cardiovascular disease

H Zhang, NS Dhalla - International Journal of Molecular Sciences, 2024 - mdpi.com
With cardiovascular disease (CVD) being a primary source of global morbidity and mortality,
it is crucial that we understand the molecular pathophysiological mechanisms at play …

Succinate induces skeletal muscle fiber remodeling via SUCNR1 signaling

T Wang, YQ Xu, YX Yuan, PW Xu, C Zhang, F Li… - EMBO …, 2019 - embopress.org
The conversion of skeletal muscle fiber from fast twitch to slow‐twitch is important for
sustained and tonic contractile events, maintenance of energy homeostasis, and the …

Cardioprotective exercise and pharmacologic interventions as complementary antidotes to cardiovascular disease

JC Quindry, BA Franklin - Exercise and sport sciences reviews, 2018 - journals.lww.com
Cardiovascular disease (CVD), including ischemic heart disease, remains a major
international public health problem (1). From an epidemiologic perspective, mitigation of …

HIF‐1α‐induced up‐regulation of microRNA‐126 contributes to the effectiveness of exercise training on myocardial angiogenesis in myocardial infarction rats

W Song, Q Liang, M Cai, Z Tian - Journal of cellular and …, 2020 - Wiley Online Library
Exercise training (ET) is a non‐drug natural rehabilitation approach for myocardial infarction
(MI). Among the numerous beneficial effects of ET, myocardial angiogenesis is …

Epitranscriptomic regulation in fasting hearts: implications for cardiac health

D Benak, K Holzerova, J Hrdlicka, F Kolar, M Olsen… - RNA biology, 2024 - Taylor & Francis
Cardiac tolerance to ischaemia can be increased by dietary interventions such as fasting,
which is associated with significant changes in myocardial gene expression. Among the …

HIF‐1α limits myocardial infarction by promoting mitophagy in mouse hearts adapted to chronic hypoxia

P Alanova, L Alan, B Opletalova… - Acta …, 2024 - Wiley Online Library
Aim The transcriptional factor HIF‐1α is recognized for its contribution to cardioprotection
against acute ischemia/reperfusion injury. Adaptation to chronic hypoxia (CH) is known to …

Two pharmacological epoxyeicosatrienoic acid-enhancing therapies are effectively antihypertensive and reduce the severity of ischemic arrhythmias in rats with …

L Cervenka, Z Husková, L Kopkan… - Journal of …, 2018 - journals.lww.com
Objective: We examined the effects of treatment with soluble epoxide hydrolase inhibitor
(sEHi) and epoxyeicosatrienoic acids (EETs) analogue (EET-A), given alone or combined …

[HTML][HTML] The effect of an adaptation to hypoxia on cardiac tolerance to ischemia/reperfusion

NV Naryzhnaya, LN Maslov, IA Derkachev… - Journal of Biomedical …, 2023 - ncbi.nlm.nih.gov
The acute myocardial infarction (AMI) and sudden cardiac death (SCD), both associated
with acute cardiac ischemia, are one of the leading causes of adult death in economically …

Aerobic exercise-induced HIF-1α upregulation in heart failure: exploring potential impacts on MCT1 and MPC1 regulation

L Xu, M Yang, A Wei, Z Wei, Y Qin, K Wang, B Li… - Molecular …, 2024 - Springer
Background The terminal stage of ischemic heart disease develops into heart failure (HF),
which is characterized by hypoxia and metabolic disturbances in cardiomyocytes. The …

[PDF][PDF] Role of protein kinase C, PI3 kinase, tyrosine kinases, NO-synthase, KATP channels and MPT pore in the signaling pathway of the cardioprotective effect of …

SY Tsibulnikov, LN Maslov, NV Naryzhnaya… - Gen Physiol …, 2018 - academia.edu
It was established that adaptation to chronic continuous normobaric hypoxia (CCNH)
increases cardiac tolerance to ischemia and reperfusion. Coronary artery occlusion (20 min) …