Tumor metastasis is the major cause of mortality from cancer. Metabolic rewiring and the
metastatic cascade are highly intertwined, co-operating to promote multiple steps of cancer …

Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA
modification, histone modification, RNA modification, chromatin remodeling, and non-coding …

NAD+ metabolism is implicated in aging and cancer. However, its role in immune checkpoint
regulation and immune evasion remains unclear. Here, we find nicotinamide …

Abnormal glucose metabolism is central to neurodegeneration, and considerable evidence
suggests that abnormalities in key enzymes of the tricarboxylic acid (TCA) cycle underlie the …

Cancer cells have the plasticity to adjust their metabolic phenotypes for survival and
metastasis. A developmental programme known as epithelial-to-mesenchymal transition …

Metastasis is responsible for 90% of deaths in patients with cancer. Understanding the role
of metabolism during metastasis has been limited by the development of robust and …

Tumor cells reprogram nutrient acquisition and metabolic pathways to meet their energetic,
biosynthetic, and redox demands. Similarly, metabolic processes in immune cells support …

Metabolic reprogramming is a hallmark of human malignancies. Dysregulation of glutamine
metabolism is essential for tumorigenesis, microenvironment remodeling, and therapeutic …

The thriving field that constitutes cancer metabolism has unveiled some groundbreaking
facts over the past two decades, at the heart of which is the TCA cycle and its intermediates …

Aberrant accumulation of succinate has been detected in many cancers. However, the
cellular function and regulation of succinate in cancer progression is not completely …