The emergence of form and function during mammalian embryogenesis is a complex
process that involves multiple regulatory levels. The foundations of the body plan are laid …

The cross-talk between stem cells and their microenvironment has been shown to have a
direct impact on stem cells' decisions about proliferation, growth, migration, and …

Naïve human pluripotent stem cells (hPSCs) provide a unique experimental platform of cell
fate decisions during pre-implantation development, but their lineage potential remains …

Isolating human MEK/ERK signaling-independent pluripotent stem cells (PSCs) with naive
pluripotency characteristics while maintaining differentiation competence and (epi) genetic …

Much attention has focussed on the conversion of human pluripotent stem cells (PSCs) to a
more naïve developmental status. Here we provide a method for resetting via transient …

Mouse embryonic stem cells derived from the epiblast contribute to the somatic lineages and
the germline but are excluded from the extra-embryonic tissues that are derived from the …

The notion that the germ line does not age goes back to the 19th-century ideas of August
Weismann. However, being metabolically active, the germ line accumulates damage and …

Human naïve pluripotent stem cells (PSCs) share features with the pre-implantation epiblast.
They therefore provide an unmatched opportunity for characterising the developmental …

Background Human pluripotent stem cells (hPSCs) provide powerful models for studying
cellular differentiations and unlimited sources of cells for regenerative medicine. However, a …

Over the past few decades, many attempts have been made to capture different states of
pluripotency in vitro. Naive and primed pluripotent stem cells, corresponding to the …