[HTML][HTML] Fibroblasts: Origins, definitions, and functions in health and disease
Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and
disease by producing complex extracellular matrix and creating signaling niches through …
disease by producing complex extracellular matrix and creating signaling niches through …
Functional hair follicle regeneration: an updated review
S Ji, Z Zhu, X Sun, X Fu - Signal Transduction and Targeted Therapy, 2021 - nature.com
The hair follicle (HF) is a highly conserved sensory organ associated with the immune
response against pathogens, thermoregulation, sebum production, angiogenesis …
response against pathogens, thermoregulation, sebum production, angiogenesis …
Ripretinib in patients with advanced gastrointestinal stromal tumours (INVICTUS): a double-blind, randomised, placebo-controlled, phase 3 trial
Background Resistance to approved inhibitors of KIT proto-oncogene, receptor tyrosine
kinase (KIT), and platelet-derived growth factor receptor α (PDGFRA) is a clinical challenge …
kinase (KIT), and platelet-derived growth factor receptor α (PDGFRA) is a clinical challenge …
[HTML][HTML] Distinct regulatory programs control the latent regenerative potential of dermal fibroblasts during wound healing
Dermal fibroblasts exhibit considerable heterogeneity during homeostasis and in response
to injury. Defining lineage origins of reparative fibroblasts and regulatory programs that drive …
to injury. Defining lineage origins of reparative fibroblasts and regulatory programs that drive …
Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state
Y Liu, CF Guerrero-Juarez, F Xiao, NU Shettigar… - Developmental cell, 2022 - cell.com
Hair follicle stem cells are regulated by dermal papilla fibroblasts, their principal signaling
niche. Overactivation of Hedgehog signaling in the niche dramatically accelerates hair …
niche. Overactivation of Hedgehog signaling in the niche dramatically accelerates hair …
Switch control inhibition of KIT and PDGFRA in patients with advanced gastrointestinal stromal tumor: a phase I study of ripretinib
F Janku, AR Abdul Razak, P Chi… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE In advanced gastrointestinal stromal tumor (GIST), there is an unmet need for
therapies that target both primary and secondary mutations of pathogenic KIT/PDGFRA …
therapies that target both primary and secondary mutations of pathogenic KIT/PDGFRA …
Dysfunction of hair follicle mesenchymal progenitors contributes to age-associated hair loss
Skin aging is accompanied by hair loss due to impairments in hair follicle (HF) epithelial
progenitor cells and their mesenchymal niche. This inductive mesenchyme, called dermal …
progenitor cells and their mesenchymal niche. This inductive mesenchyme, called dermal …
[HTML][HTML] Status of research on the development and regeneration of hair follicles
D Liu, Q Xu, X Meng, X Liu, J Liu - International Journal of Medical …, 2024 - ncbi.nlm.nih.gov
Hair loss, or alopecia, is a prevalent condition in modern society that imposes substantial
mental and psychological burden on individuals. The types of hair loss, include …
mental and psychological burden on individuals. The types of hair loss, include …
[HTML][HTML] Effective and economical cell therapy for hair regeneration
JH Sung - Biomedicine & Pharmacotherapy, 2023 - Elsevier
We reviewed and summarized the latest reports on the characteristics of stem cells and
follicular cells that are under development for hair loss treatment. Compared with …
follicular cells that are under development for hair loss treatment. Compared with …
Polygonum multiflorum extract support hair growth by elongating anagen phase and abrogating the effect of androgen in cultured human dermal papilla cells
Abstract Background Dermal papilla cells (DPCs) play a key role in hair growth among the
various cell types in hair follicles. Especially, DPCs determine the fate of hair follicle such as …
various cell types in hair follicles. Especially, DPCs determine the fate of hair follicle such as …