Human epidermal growth factor receptor 2 (HER2)-specific chimeric antigen receptor (CAR) for tumor immunotherapy; recent progress
Due to the overexpression or amplification of human epidermal growth factor receptor 2
(HER2) with poor prognosis in a myriad of human tumors, recent studies have focused on …
(HER2) with poor prognosis in a myriad of human tumors, recent studies have focused on …
Recent advances in HER2 positive breast cancer epigenetics: Susceptibility and therapeutic strategies
HER2 amplification/overexpression accounts for aggressive clinical features of HER2
positive breast cancer. Epigenetic changes including DNA methylation, histone …
positive breast cancer. Epigenetic changes including DNA methylation, histone …
Synthesis and biological evaluation of pyrimidine bridged combretastatin derivatives as potential anticancer agents and mechanistic studies
A number of pyrimidine bridged combretastatin derivatives were designed, synthesized and
evaluated for anticancer activities against breast cancer (MCF-7) and lung cancer (A549) …
evaluated for anticancer activities against breast cancer (MCF-7) and lung cancer (A549) …
[HTML][HTML] Pyrotinib combined with vinorelbine in patients with previously treated HER2-positive metastatic breast cancer: a multicenter, single-arm, prospective study
K Jiang, R Hong, W Xia, Q Lu, L Li… - Cancer Research and …, 2024 - ncbi.nlm.nih.gov
Purpose This study aims to evaluate the efficacy and safety of a new combination treatment
of vinorelbine and pyrotinib in human epidermal growth factor receptor 2 (HER2)–positive …
of vinorelbine and pyrotinib in human epidermal growth factor receptor 2 (HER2)–positive …
miR‐126 reduces trastuzumab resistance by targeting PIK3R2 and regulating AKT/mTOR pathway in breast cancer cells
R Fu, JS Tong - Journal of cellular and molecular medicine, 2020 - Wiley Online Library
MicroRNAs (miRNAs) have been found to play a key role in drug resistance. In the current
study, we aimed to explore the potential role of miR‐126 in trastuzumab resistance in breast …
study, we aimed to explore the potential role of miR‐126 in trastuzumab resistance in breast …
Design, synthesis and evaluation of cytotoxic, antimicrobial, and anti-HIV-1 activities of new 1, 2, 3, 4-tetrahydropyrimidine derivatives
N Razzaghi-Asl, M Kamrani-Moghadam… - Research in …, 2019 - journals.lww.com
Abstract A series of new 1, 2, 3, 4-tetrahydropyrimidine (THPM) derivatives were designed
and synthesized within a one-pot three component Biginelli reaction. The structures of …
and synthesized within a one-pot three component Biginelli reaction. The structures of …
Genomic alterations associated with HER2+ breast cancer risk and clinical outcome in response to trastuzumab
Human epidermal growth factor receptor 2 positive (HER2+) breast cancer (BC) is an
aggressive BC subtype characterized by HER2 overexpression/amplification. Genomic …
aggressive BC subtype characterized by HER2 overexpression/amplification. Genomic …
Human epidermal growth receptor polymorphisms (HER1–rs11543848 and HER2–rs1136201) exhibited significant association with breast cancer risk in Pashtun …
W Sombal, NU Khan, BM Khan, M Ismail… - Health Science …, 2024 - Wiley Online Library
Abstract Background and Aims Breast cancer is the most common type of cancer in women.
The genetic polymorphism in HER (HER1–rs11543848 and HER2–rs1136201) were found …
The genetic polymorphism in HER (HER1–rs11543848 and HER2–rs1136201) were found …
HER2 tyrosine kinase inhibitors in the sensitization to cancers resistant to HER2 antibodies
H Singla, A Munshi - Critical Reviews™ in Oncogenesis, 2020 - dl.begellhouse.com
Human epidermal growth factor receptor (HER2) is a well-established histopathological
marker. It is aberrantly expressed in various cancers, predominantly in breast cancer. HER2 …
marker. It is aberrantly expressed in various cancers, predominantly in breast cancer. HER2 …
Purine derivatives with heterocyclic moieties and related analogs as new antitumor agents
N Fernández-Sáez, B Rubio-Ruiz… - Future medicinal …, 2019 - Taylor & Francis
Aim: Identification of new antiproliferative compounds. Methodology: Four series of
compounds were synthesized by the Mitsunobu reaction. Their antiproliferative activity was …
compounds were synthesized by the Mitsunobu reaction. Their antiproliferative activity was …