Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …

Physical activity is one of the modifiable factors of cognitive decline and dementia with the
strongest evidence. Although many influential reviews have illustrated the neurobiological …

Physical exercise (PE) improves physical performance, mental status, general health, and
well-being. It does so by affecting many mechanisms at the cellular and molecular level. PE …

Depression is a major health problem with a high prevalence and a heavy socioeconomic
burden in western societies. It is associated with atrophy and impaired functioning of cortico …

A decade has passed since we published a comprehensive review in this journal
addressing the topic of promoting successful cognitive aging, making this a good time to …

It has been well documented that neurotrophins, including brain-derived neurotrophic factor
(BDNF), are severely affected in Alzheimer's disease (AD), but their administration faces a …

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that has pleiotropic effects on
neuronal morphology and synaptic plasticity that underlie hippocampal circuit development …

Depression is one of the most common psychiatric conditions, characterized by significant
and persistent depressed mood and diminished interest, and often coexists with various …

Spinal cord injury (SCI) causes motor, sensory and automatic impairment due to rarely axon
regeneration. Developing effective treatment for SCI in the clinic is extremely challenging …

Alzheimer's disease (AD) is characterized by amyloid (A) β peptide accumulation and
intracellular neurofibrillary tangles. New hypotheses have suggested that AD involves …