Horizontal gene transfer of antibiotic resistance genes in biofilms

C Michaelis, E Grohmann - Antibiotics, 2023 - mdpi.com
Most bacteria attach to biotic or abiotic surfaces and are embedded in a complex matrix
which is known as biofilm. Biofilm formation is especially worrisome in clinical settings as it …

Eco-evolutionary dynamics linked to horizontal gene transfer in Vibrios

F Le Roux, M Blokesch - Annual review of microbiology, 2018 - annualreviews.org
Vibrio is a genus of ubiquitous heterotrophic bacteria found in aquatic environments.
Although they are a small percentage of the bacteria in these environments, vibrios can …

The Drosophila immune deficiency pathway modulates enteroendocrine function and host metabolism

L Kamareddine, WP Robins, CD Berkey, JJ Mekalanos… - Cell metabolism, 2018 - cell.com
Enteroendocrine cells (EEs) are interspersed between enterocytes and stem cells in the
Drosophila intestinal epithelium. Like enterocytes, EEs express components of the immune …

Microbiota-derived acetate activates intestinal innate immunity via the Tip60 histone acetyltransferase complex

BE Jugder, L Kamareddine, PI Watnick - Immunity, 2021 - cell.com
Microbe-derived acetate activates the Drosophila immunodeficiency (IMD) pathway in a
subset of enteroendocrine cells (EECs) of the anterior midgut. In these cells, the IMD …

Regulating metabolism to shape immune function: Lessons from Drosophila

ML Bland - Seminars in cell & developmental biology, 2023 - Elsevier
Infection with pathogenic microbes is a severe threat that hosts manage by activating the
innate immune response. In Drosophila melanogaster, the Toll and Imd signaling pathways …

Diagnosis of biofilm infections: Current methods used, challenges and perspectives for the future

NBS Silva, LA Marques… - Journal of Applied …, 2021 - academic.oup.com
The diagnosis of biofilms continues to be a challenge, and there is no standardized protocol
for such a diagnosis in clinical practice. In addition, some proposed methodologies are …

Vibrio cholerae high cell density quorum sensing activates the host intestinal innate immune response

BE Jugder, JH Batista, JA Gibson, PM Cunningham… - Cell reports, 2022 - cell.com
Quorum sensing fundamentally alters the interaction of Vibrio cholerae with aquatic
environments, environmental hosts, and the human intestine. At high cell density, the …

Drosophila as a Model Organism in Host–Pathogen Interaction Studies

S Younes, A Al-Sulaiti, EAA Nasser, H Najjar… - Frontiers in cellular …, 2020 - frontiersin.org
Owing to the genetic similarities and conserved pathways between a fruit fly and mammals,
the use of the Drosophila model as a platform to unveil novel mechanisms of infection and …

Commensal pathogen competition impacts host viability

D Fast, B Kostiuk, E Foley… - Proceedings of the …, 2018 - National Acad Sciences
While the structure and regulatory networks that govern type-six secretion system (T6SS)
activity of Vibrio cholerae are becoming increasingly clear, we know less about the role of …

Environmental role of pathogenic traits in Vibrio cholerae

SN Sakib, G Reddi, S Almagro-Moreno - 2018 - Am Soc Microbiol
Vibrio cholerae is a natural inhabitant of aquatic ecosystems. Some strains of V. cholerae
can colonize human hosts and cause cholera, a profuse watery diarrhea. The major …