Iron is a transition metal and essential constituent of almost all living cells and organisms. As
component of various metalloproteins it is involved in critical biochemical processes such as …

Exposure to a variety of toxins and/or infectious agents leads to disease, degeneration and
death, often characterised by circumstances in which cells or tissues do not merely die and …

Iron is an essential cofactor for important biological activities and biochemical reactions,
including the transport of oxygen via red blood cells and its reduction to water during …

The endothelium is essential for the maintenance of vascular homeostasis. Central to this
role is the production of endothelium-derived nitric oxide (EDNO), synthesized by the …

Normal metabolism is associated with unavoidable mild oxidative stress resulting in
biomolecular damage that cannot be totally repaired or removed by cellular degradative …

The lysosomal compartment is essential for a variety of cellular functions, including the
normal turnover of most long-lived proteins and all organelles. The compartment consists of …

The lysosomal compartment consists of numerous acidic vesicles (pH~ 4–5) that constantly
fuse and divide. It receives a large number of hydrolases from the trans-Golgi network, while …

Iron is the most abundant transition metal in the earth's crust. It cycles easily between ferric
(oxidized; Fe (III)) and ferrous (reduced; Fe (II)) and readily forms complexes with oxygen …

Alzheimer's disease (AD) is a common form of dementia in aged people, which is defined by
two pathological characteristics: β-amyloid protein (Aβ) deposition and tau …

The lysosomal compartment is the place for cellular degradation of endocytosed and
autophagocytosed material and a center for normal turnover of organelles as well as most …