Systemic mechanisms of necrotic cell debris clearance

S Schuermans, C Kestens, PE Marques - Cell Death & Disease, 2024 - nature.com
Necrosis is an overarching term that describes cell death modalities caused by (extreme)
adverse conditions in which cells lose structural integrity. A guaranteed consequence of …

Neutrophil extracellular traps in homeostasis and disease

H Wang, SJ Kim, Y Lei, S Wang, H Wang… - … and Targeted Therapy, 2024 - nature.com
Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are
renowned for their propensity to expel decondensed chromatin embedded with inflammatory …

Neutrophil extracellular traps induce persistent lung tissue damage via thromboinflammation without altering virus resolution in a mouse coronavirus model

M Salzmann, P Gibler, P Haider, M Brekalo… - Journal of Thrombosis …, 2024 - Elsevier
Background During infection, neutrophil extracellular traps (NETs) are associated with
severity of pulmonary diseases such as acute respiratory disease syndrome. NETs induce …

Targeting Neutrophil Extracellular Trap Formation: Exploring Promising Pharmacological Strategies for the Treatment of Preeclampsia

LL Hernández González, L Pérez-Campos Mayoral… - Pharmaceuticals, 2024 - mdpi.com
Neutrophils, which constitute the most abundant leukocytes in human blood, emerge as
crucial players in the induction of endothelial cell death and the modulation of endothelial …

Lacticaseibacillus rhamnosus CRL1505 Peptidoglycan Modulates the Inflammation-Coagulation Response Triggered by Poly(I:C) in the Respiratory Tract

H Zelaya, L Arellano-Arriagada, K Fukuyama… - International Journal of …, 2023 - mdpi.com
Lacticaseibacillus rhamnosus CRL1505 beneficially modulates the inflammation-
coagulation response during respiratory viral infections. This study evaluated the capacity of …

What is the actual relationship between neutrophil extracellular traps and COVID-19 severity? A longitudinal study

C de Diego, AB Lasierra, L López-Vergara… - Respiratory …, 2024 - Springer
Abstract Background Neutrophil extracellular traps (NETs) have repeatedly been related to
COVID-19 severity and mortality. However, there is no consensus on their quantification …

Targeting extranuclear histones to alleviate acute and chronic inflammation

GAF Nicolaes, O Soehnlein - Trends in Pharmacological Sciences, 2024 - cell.com
Extracellular histones instigate an inflammatory triad–centered on cytotoxicity, immune cell
stimulation, and coagulation–ultimately shaping the dynamics and outcome of various …

Delving into the clinical impact of NETs in pediatric cancer

N Benavent, A Cañete, B Argilés, A Juan-Ribelles… - Pediatric …, 2024 - nature.com
Pediatric cancer, a complex and heterogeneous group of diseases, continues to challenge
medical research and treatment strategies. Despite advances in precision medicine and …

Targeting neutrophil extracellular trap accumulation under flow in patients with immune-mediated thrombotic thrombocytopenic purpura

N Yada, Q Zhang, A Bignotti, SH Gralnek… - Blood …, 2024 - ashpublications.org
Neutrophil NETosis is a unique form of cell death, characterized by the release of
decondensed chromatin and antimicrobial contents to the extracellular space, which is …

Neutrophil PPIF exacerbates lung ischemia–reperfusion injury after lung transplantation by promoting calcium overload-induced neutrophil extracellular traps …

W Wu, F Meng, H Zhang, H Tian, X Zhang - International …, 2024 - Elsevier
Lung ischemia–reperfusion (I/R) injury is the main risk factor for primary graft dysfunction
and patient death after lung transplantation (LTx). It is widely accepted that the main …