Cardiovascular disease is a leading cause of morbidity and mortality in the Western world.
Studies of sortilin's influence on cardiovascular and metabolic diseases goes far beyond the …

The present review provides a summary of recent evidence of sortilin expression, function,
and regulation and its implications in lipid metabolism and development of lipid disorder …

Progranulin (PGRN) haploinsufficiency associated with loss-of-function mutations in the
granulin gene causes frontotemporal dementia (FTD). This suggests that increasing PGRN …

Rationale: Genome-wide association studies identified single-nucleotide polymorphisms
near the SORT1 locus strongly associated with decreased plasma LDL-C (low-density …

Several lines of evidence have shown that SORT1 gene within 1p13. 3 locus is an important
modulator of the low-density lipoprotein-cholesterol (LDL-C) level and atherosclerosis risk …

Psoriasis is a systemic, immune-metabolic disease with strong genetic predispositions and
autoimmune pathogenic traits. During psoriasis progression, a wide spectrum of …

ApoB lipoproteins (apo B-Lp) are produced in hepatocytes, and their secretion requires the
cargo receptor sortilin. We examined the secretion of apo B-Lp-containing very low-density …

Studies examining the relationship between cellular sortilin and VLDL-B100 secretion
demonstrate inconsistent results. Current studies explore the possibility that discrepancies …

Sortilin is a multi-ligand sorting receptor that interacts with B100-containing VLDL and LDL
as well as other ligands including neurotensin (NT). The current study investigates the …

Antibodies are proteins that play a crucial role in the immune defense mechanism of living
organisms. They recognize and neutralize specific foreign substances or proteins (antigens) …