High-grade serous ovarian cancer, also known as high-grade serous carcinoma (HGSC), is
the most common and deadliest type of ovarian cancer. HGSC appears to arise from the …

The biology of ovarian carcinoma differs from that of hematogenously metastasizing tumors
because ovarian cancer cells primarily disseminate within the peritoneal cavity and are only …

The cell-of-origin of high grade serous ovarian carcinoma (HGSOC) remains controversial,
with fallopian tube epithelium (FTE) and ovarian surface epithelium (OSE) both considered …

High-grade serous ovarian carcinoma presents significant clinical and therapeutic
challenges. Although the traditional model of carcinogenesis has focused on the ovary as a …

Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

Ovarian clear-cell carcinoma (OCCC) is an aggressive form of ovarian cancer with high
ARID1A mutation rates. Here we present a mutant mouse model of OCCC. We find that …

The retinoblastoma (RB) tumour suppressor gene is functionally inactivated in a broad
range of paediatric and adult cancers, and a plethora of cellular functions and partners have …

Ovarian carcinomas are a heterogeneous group of neoplasms and are traditionally
subclassified based on type and degree of differentiation. Although current clinical …

Although ovarian cancer is the most lethal gynecologic malignancy in women, little is known
about how the cancer initiates and metastasizes. In the last decade, new evidence has …

Following a period of slow progress, the completion of genome sequencing and the
paradigm shift relative to the cell of origin for high grade serous ovarian cancer (HGSOC) led …