A new era for understanding amyloid structures and disease

MG Iadanza, MP Jackson, EW Hewitt… - … reviews Molecular cell …, 2018 - nature.com
The aggregation of proteins into amyloid fibrils and their deposition into plaques and
intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition …

Biomarkers for Alzheimer's disease: current status and prospects for the future

K Blennow, H Zetterberg - Journal of internal medicine, 2018 - Wiley Online Library
Accumulating data from the clinical research support that the core Alzheimer's disease (AD)
cerebrospinal fluid (CSF) biomarkers amyloid‐β (Aβ42), total tau (T‐tau), and …

CSF tau microtubule-binding region identifies pathological changes in primary tauopathies

K Horie, NR Barthélemy, S Spina, L VandeVrede… - Nature medicine, 2022 - nature.com
Despite recent advances in fluid biomarker research in Alzheimer's disease (AD), there are
no fluid biomarkers or imaging tracers with utility for diagnosis and/or theragnosis available …

Advantages and disadvantages of the use of the CSF Amyloid β (Aβ) 42/40 ratio in the diagnosis of Alzheimer's Disease

O Hansson, S Lehmann, M Otto, H Zetterberg… - Alzheimer's research & …, 2019 - Springer
The cerebrospinal fluid (CSF) biochemical markers (biomarkers) Amyloidβ 42 (Aβ 42), total
Tau (T-tau) and Tau phosphorylated at threonine 181 (P-tau 181) have proven diagnostic …

Current state of Alzheimer's fluid biomarkers

JL Molinuevo, S Ayton, R Batrla, MM Bednar… - Acta …, 2018 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disease with a complex and
heterogeneous pathophysiology. The number of people living with AD is predicted to …

Progression of cerebral amyloid angiopathy: a pathophysiological framework

EA Koemans, JP Chhatwal, SJ van Veluw… - The Lancet …, 2023 - thelancet.com
Cerebral amyloid angiopathy, which is defined by cerebrovascular deposition of amyloid β,
is a common age-related small vessel pathology associated with intracerebral haemorrhage …

Diagnosis of Alzheimer's disease utilizing amyloid and tau as fluid biomarkers

JC Lee, SJ Kim, S Hong, YS Kim - Experimental & molecular medicine, 2019 - nature.com
Current technological advancements in clinical and research settings have permitted a more
intensive and comprehensive understanding of Alzheimer's disease (AD). This development …

Mediterranean diet, Alzheimer disease biomarkers, and brain atrophy in old age

T Ballarini, D Melo van Lent, J Brunner, A Schröder… - Neurology, 2021 - AAN Enterprises
Objective To determine whether following a Mediterranean-like diet (MeDi) relates to
cognitive functions and in vivo biomarkers for Alzheimer disease (AD), we analyzed cross …

Amyloid biomarkers in Alzheimer's disease

K Blennow, N Mattsson, M Schöll, O Hansson… - Trends in …, 2015 - cell.com
Aggregation of amyloid-β (Aβ) into oligomers, fibrils, and plaques is central in the molecular
pathogenesis of Alzheimer's disease (AD), and is the main focus of AD drug development …

Alzheimer disease

DS Knopman, H Amieva, RC Petersen… - Nature reviews Disease …, 2021 - nature.com
Alzheimer disease (AD) is biologically defined by the presence of β-amyloid-containing
plaques and tau-containing neurofibrillary tangles. AD is a genetic and sporadic …