Development and functions of the choroid plexus–cerebrospinal fluid system

MP Lun, ES Monuki, MK Lehtinen - Nature Reviews Neuroscience, 2015 - nature.com
The choroid plexus (ChP) is the principal source of cerebrospinal fluid (CSF), which has
accepted roles as a fluid cushion and a sink for nervous system waste in vertebrates …

A primer for morpholino use in zebrafish

BR Bill, AM Petzold, KJ Clark, LA Schimmenti… - Zebrafish, 2009 - liebertpub.com
Morpholino oligonucleotides are the most common anti-sense “knockdown” technique used
in zebrafish (Danio rerio). This review discusses common practices for the design …

The choroid plexus in healthy and diseased brain

C Kaur, G Rathnasamy, EA Ling - Journal of Neuropathology & …, 2016 - academic.oup.com
The choroid plexus is composed of epithelial cells resting on a basal lamina. These cells
produce the cerebrospinal fluid (CSF), which has many functions including rendering …

Experimental approaches for manipulating choroid plexus epithelial cells

A Jang, MK Lehtinen - Fluids and barriers of the CNS, 2022 - Springer
Choroid plexus (ChP) epithelial cells are crucial for the function of the blood-cerebrospinal
fluid barrier (BCSFB) in the developing and mature brain. The ChP is considered the primary …

Phase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium study

M Fouladi, CF Stewart, J Olson, LM Wagner… - Journal of Clinical …, 2011 - ascopubs.org
Purpose To estimate the maximum-tolerated dose (MTD), describe dose-limiting toxicities
(DLTs), and characterize pharmacokinetic properties of MK-0752, a gamma secretase …

Regulation of choroid plexus development and its functions

P Kompaníková, V Bryja - Cellular and Molecular Life Sciences, 2022 - Springer
The choroid plexus (ChP) is an extensively vascularized tissue that protrudes into the brain
ventricular system of all vertebrates. This highly specialized structure, consisting of the …

The choroid plexuses and their impact on developmental neurogenesis

PA Johansson - Frontiers in neuroscience, 2014 - frontiersin.org
During brain development the neural stem cells are regulated by both intrinsic and extrinsic
sources. One site of origin of extrinsic regulation is the developing choroid plexuses, primely …

A transgenic zebrafish model for the in vivo study of the blood and choroid plexus brain barriers using claudin 5

LM van Leeuwen, RJ Evans, KK Jim… - Biology …, 2018 - journals.biologists.com
The central nervous system (CNS) has specific barriers that protect the brain from potential
threats and tightly regulate molecular transport. Despite the critical functions of the CNS …

Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus

X Huang, T Ketova, JT Fleming, H Wang, SK Dey… - 2009 - journals.biologists.com
Choroid plexuses (ChPs) are vascularized secretory organs involved in the regulation of
brain homeostasis, and function as the blood-cerebrospinal fluid (CSF) barrier. Despite their …

Methods for studying the zebrafish brain: past, present and future

C Wyatt, EM Bartoszek, E Yaksi - European Journal of …, 2015 - Wiley Online Library
The zebrafish (Danio rerio) is one of the most promising new model organisms. The
increasing popularity of this amazing small vertebrate is evident from the exponentially …