Medicinal inorganic chemistry offers additional opportunities for the design of therapeutic
agents not accessible to organic compounds. 1− 3 The wide range of coordination numbers …

Copper (Cu) is an integral part of many important enzymes involved in a number of vital
biological processes. Although normally bound to proteins, Cu may be released and …

Metal-based antitumor drugs play a relevant role in antiblastic chemotherapy. Cisplatin is
regarded as one of the most effective drugs, even if severe toxicities and drug resistance …

Copper ions, either alone or in copper complexes, have been used to disinfect liquids, solids
and human tissue for centuries. Today copper is used as a water purifier, algaecide …

Reactive species generated by chemicals and UV radiation can cause sequence-specific
DNA damage and play important roles in mutagenesis, carcinogenesis and aging. We have …

Metal ions play an important role in biological systems, and without their catalytic presence
in trace or ultratrace amounts many essential co-factors for many biochemical reactions …

Simple Summary Organometallics, such as copper compounds, are cancer
chemotherapeutics used alone or in combination with other drugs. One small group of …

Several plant‐derived polyphenolic compounds are considered to possess anticancer and
apoptosis‐inducing properties in cancer cells. Such compounds are recognized as naturally …

Plant polyphenols are important components of human diet and a number of them are
considered to possess chemopreventive and therapeutic properties against cancer. They …

Covalent or non-covalent interactions with DNA are the basis for many potential biomedical
applications of copper complexes, ranging from DNA structural probes and footprinting …