Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

Comparative studies of ethnically diverse human populations, particularly in Africa, are
important for reconstructing human evolutionary history and for understanding the genetic …

Advances in solid drug nanoparticle technologies have resulted in a number of long-acting
(LA) formulations with the potential for once monthly or longer administration. Such …

The current 'fixed-dosage strategy'approach to medicine, means there is much inter-
individual variation in drug response. Pharmacogenetics is the study of how inter-individual …

Mounting evidence demonstrates that CYP2B6 plays a much larger role in human drug
metabolism than was previously believed. The discovery of multiple important substrates of …

Objective OATP1B1 and OATP1B3 are major hepatic drug transporters whilst OATP1A2 is
mainly located in the brain but is also located in liver and several other organs. These …

Objectives Prior candidate gene studies have associated CYP2B6 516G→ T [rs3745274]
and 983T→ C [rs28399499] with increased plasma efavirenz exposure. We sought to …

Objective: Nevirapine is widely prescribed for HIV-1 infection. We characterized
relationships between nevirapine-associated cutaneous and hepatic adverse events and …

Importance of the field: The use of the first generation non-nucleoside reverse transcriptase
inhibitor efavirenz (EFV) as a component of first-line antiretroviral therapy has been …

CYP2B6 is mainly expressed in the liver that has been thought historically to play an
insignificant role in human drug metabolism. However, increased interest in this enzyme has …