The tumor suppressor p53 functions primarily as a transcription factor. Mutation of the TP53
gene alters its response pathway, and is central to the development of many cancers. The …

Antitumor therapeutic strategies that fundamentally rely on the induction of DNA damage to
eradicate and inhibit the growth of cancer cells are integral approaches to cancer therapy …

The ataxia-telangiectasia mutated (ATM) protein kinase is a master regulator of the DNA
damage response, and it coordinates checkpoint activation, DNA repair, and metabolic …

A growing number of studies are revealing that cells can send and receive information by
controlling the temporal behavior (dynamics) of their signaling molecules. In this Review, we …

Cell cycle checkpoints activated by DNA double-strand breaks (DSBs) are essential for the
maintenance of the genomic integrity of proliferating cells. Following DNA damage, cells …

Apoptosis is a form of programmed and controlled cell death that accounts for the majority of
cellular death in bioprocesses. Cell death affects culture longevity and product quality; it is …

Cells transmit information through molecular signals that often show complex dynamical
patterns. The dynamic behavior of the tumor suppressor p53 varies depending on the …

Genome instability contributes to cancer development and accelerates age-related
pathologies as evidenced by a variety of congenital cancer susceptibility and progeroid …

How signaling dynamics encode information is a central question in biology. During
vertebrate development, dynamic Notch signaling oscillations control segmentation of the …

Many biological networks respond to various inputs through a common signaling molecule
that triggers distinct cellular outcomes. One potential mechanism for achieving specific input …