Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant
tumours that can arise at any point of the biliary tree. Their incidence is increasing globally …

The Hippo signalling pathway has emerged as a major player in many aspects of liver
biology, such as development, cell fate determination, homeostatic function and …

Cholangiocarcinoma is a disease entity comprising diverse epithelial tumours with features
of cholangiocyte differentiation: cholangiocarcinomas are categorized according to …

Tumour microenvironment is a complex, multicellular functional compartment that,
particularly when assembled as an abundant desmoplastic reaction, may profoundly affect …

YAP and TAZ are intracellular messengers communicating multiple interacting extracellular
biophysical and biochemical cues to the transcription apparatus in the nucleus and back to …

The Hippo pathway is the key player in various signaling processes, including organ
development and maintenance of tissue homeostasis. This pathway comprises a core …

Cholangiocarcinomas (CCAs) are diverse epithelial tumors arising from the liver or large
bile ducts with features of cholangiocyte differentiation. CCAs are classified anatomically …

Abstract Background RNA N6-Methyladenosine (m6A) modification is implicated in the
progression of human cancers including cholangiocarcinoma (CCA). METTL16 is recently …

Cholangiocarcinoma (CCA) is a highly-aggressive malignancy arising from the biliary tree,
characterized by a steady increase in incidence globally and a high mortality rate. Most …

Abstract The Hippo pathway effector, Yes-associated protein (YAP), is a transcriptional
coactivator implicated in cholangiocarcinoma (CCA) pathogenesis. YAP is known to be …