[HTML][HTML] Importance of drug pharmacokinetics at the site of action
BACKGROUND Due to difficulty in accessing relevant tissues or biological fluids to measure
drug levels, plasma drug concentrations are often collected with the hope that they will …
drug levels, plasma drug concentrations are often collected with the hope that they will …
Imaging of anticancer drug action in single cells
MA Miller, R Weissleder - Nature Reviews Cancer, 2017 - nature.com
Imaging is widely used in anticancer drug development, typically for whole-body tracking of
labelled drugs to different organs or to assess drug efficacy through volumetric …
labelled drugs to different organs or to assess drug efficacy through volumetric …
Increased Tumor Penetration of Single-Domain Antibody–Drug Conjugates Improves In Vivo Efficacy in Prostate Cancer Models
Targeted delivery of chemotherapeutics aims to increase efficacy and lower toxicity by
concentrating drugs at the site-of-action, a method embodied by the seven current FDA …
concentrating drugs at the site-of-action, a method embodied by the seven current FDA …
Improved tumor penetration and single-cell targeting of antibody–drug conjugates increases anticancer efficacy and host survival
C Cilliers, B Menezes, I Nessler, J Linderman… - Cancer research, 2018 - AACR
Current antibody–drug conjugates (ADC) have made advances in engineering the antibody,
linker, conjugation site, small-molecule payload, and drug-to-antibody ratio (DAR). However …
linker, conjugation site, small-molecule payload, and drug-to-antibody ratio (DAR). However …
Multiscale modeling of antibody-drug conjugates: connecting tissue and cellular distribution to whole animal pharmacokinetics and potential implications for efficacy
C Cilliers, H Guo, J Liao, N Christodolu, GM Thurber - The AAPS journal, 2016 - Springer
Antibody-drug conjugates exhibit complex pharmacokinetics due to their combination of
macromolecular and small molecule properties. These issues range from systemic …
macromolecular and small molecule properties. These issues range from systemic …
Tracking antibody distribution with near-infrared fluorescent dyes: impact of dye structure and degree of labeling on plasma clearance
C Cilliers, I Nessler, N Christodolu… - Molecular …, 2017 - ACS Publications
Monoclonal antibodies labeled with near-infrared (NIR) fluorophores have potential use in
disease detection, intraoperative imaging, and pharmacokinetic characterization of …
disease detection, intraoperative imaging, and pharmacokinetic characterization of …
Cellular-resolution imaging of bystander payload tissue penetration from antibody-drug conjugates
After several notable clinical failures in early generations, antibody–drug conjugates (ADC)
have made significant gains with seven new FDA approvals within the last 3 years. These …
have made significant gains with seven new FDA approvals within the last 3 years. These …
Antibody Co-Administration Can Improve Systemic and Local Distribution of Antibody–Drug Conjugates to Increase In Vivo Efficacy
JF Ponte, L Lanieri, E Khera, R Laleau, O Ab… - Molecular cancer …, 2021 - AACR
Several antibody–drug conjugates (ADC) showing strong clinical responses in solid tumors
target high expression antigens (HER2, TROP2, Nectin-4, and folate receptor alpha/FRα) …
target high expression antigens (HER2, TROP2, Nectin-4, and folate receptor alpha/FRα) …
Impact of synthesis methods on the functionality of antibody-conjugated gold nanoparticles for targeted therapy
A Anaki, C Tzror-Azankot, M Motiei, T Sadan… - Nanoscale …, 2024 - pubs.rsc.org
Gold nanoparticles (GNPs) are emerging as promising modular platforms for antibody-
based cancer therapeutics. Their unique physiochemical properties enable efficient binding …
based cancer therapeutics. Their unique physiochemical properties enable efficient binding …
Anchor, spacer, and ligand-modified engineered exosomes for trackable targeted therapy
Exosomes have been widely demonstrated as an effective anticancer therapeutic moiety.
However, their clinical translation has been limited by the requirement of prohibitively high …
However, their clinical translation has been limited by the requirement of prohibitively high …