Inflammation underlies many chronic and degenerative diseases, but it also mitigates
infections, clears damaged cells and initiates tissue repair. Many of the mechanisms that link …

Background Insulin resistance (IR) is one of the major hallmark for pathogenesis and
etiology of type 2 diabetes mellitus (T2DM). IR is directly interlinked with various …

Increased oxidative stress has been suggested to initiate and promote tumorigenesis by
inducing DNA damage and to suppress tumor development by triggering apoptosis and …

Ischemia and reperfusion–elicited tissue injury contributes to morbidity and mortality in a
wide range of pathologies, including myocardial infarction, ischemic stroke, acute kidney …

Kaempferol is a polyphenol antioxidant found in fruits and vegetables. Many studies have
described the beneficial effects of dietary kaempferol in reducing the risk of chronic …

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a devastating disease
that can be caused by a variety of conditions including pneumonia, sepsis, trauma, and most …

Cell-type plasticity within a tumor has recently been suggested to cause a bidirectional
conversion between tumor-initiating stem cells and nonstem cells triggered by an …

This review deals with emerging evidence of an association between systemic or local
hypoxia and inflammation in a variety of diseases. The evidence points to new ways of …

Inflammation is a fundamental protective response that sometimes goes awry and becomes
a major cofactor in the pathogenesis of many chronic human diseases, including cancer …

The nuclear factor NF-κB pathway has long been considered a prototypical proinflammatory
signaling pathway, largely based on the role of NF-κB in the expression of proinflammatory …