Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution

J Zahradník, S Marciano, M Shemesh, E Zoler… - Nature …, 2021 - nature.com
SARS-CoV-2 variants of interest and concern will continue to emerge for the duration of the
COVID-19 pandemic. To map mutations in the receptor-binding domain (RBD) of the spike …

COVID-19 drug discovery and treatment options

JFW Chan, S Yuan, H Chu, S Sridhar… - Nature Reviews …, 2024 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused substantial morbidity and …

SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target

B Xia, X Shen, Y He, X Pan, FL Liu, Y Wang, F Yang… - Cell research, 2021 - nature.com
Cytokine storm and multi-organ failure are the main causes of SARS-CoV-2-related death.
However, the origin of excessive damages caused by SARS-CoV-2 remains largely …

[HTML][HTML] Natural triterpenoids from licorice potently inhibit SARS-CoV-2 infection

Y Yi, J Li, X Lai, M Zhang, Y Kuang, YO Bao… - Journal of advanced …, 2022 - Elsevier
Introduction The COVID-19 global epidemic caused by severe acute respiratory syndrome
coronavirus (SARS-CoV-2) is a great public health emergency. Discovering antiviral drug …

SARS-CoV-2 RBD in vitro evolution follows contagious mutation spread, yet generates an able infection inhibitor

J Zahradník, S Marciano, M Shemesh, E Zoler… - BioRxiv, 2021 - biorxiv.org
SARS-CoV-2 is continually evolving, with more contagious mutations spreading rapidly.
Using in vitro evolution to affinity maturate the receptor-binding domain (RBD) of the spike …

Electrochemical immunosensor for rapid and highly sensitive detection of SARS-CoV-2 antigen in the nasal sample

M Mehmandoust, ZP Gumus, M Soylak, N Erk - Talanta, 2022 - Elsevier
A label-free electrochemical biosensing approach as an appropriate analysis technique for
SARS-CoV-2 spike protein (SARS-CoV-2 S-protein) was investigated to facilitate the …

An IgM-like inhalable ACE2 fusion protein broadly neutralizes SARS-CoV-2 variants

J Liu, F Mao, J Chen, S Lu, Y Qi, Y Sun, L Fang… - Nature …, 2023 - nature.com
Many of the currently available COVID-19 vaccines and therapeutics are not effective
against newly emerged SARS-CoV-2 variants. Here, we developed the metallo-enzyme …

Epigallocatechin gallate (EGCG) attenuates severe acute respiratory coronavirus disease 2 (SARS-CoV-2) infection by blocking the interaction of SARS-CoV-2 spike …

T Ohishi, T Hishiki, MS Baig, S Rajpoot, U Saqib… - PLoS …, 2022 - journals.plos.org
The outbreak of the coronavirus disease 2019 caused by the severe acute respiratory
syndrome coronavirus 2 triggered a global pandemic where control is needed through …

A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants

Y Du, R Shi, Y Zhang, X Duan, L Li, J Zhang… - Nature …, 2021 - nature.com
The successive emergences and accelerating spread of novel severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) lineages and evolved resistance to some ongoing …