Controlled release of promoter-proximal paused RNA polymerase II (RNA Pol II) is crucial
for gene regulation. However, studying RNA Pol II pausing is challenging, as pause-release …

Signaling interactions are important during skeletal muscle regeneration, where muscle
cells in distinct states (quiescent, reactivated, proliferating and differentiated) must …

The centrosome is an evolutionarily conserved, ancient organelle whose role in cell division
was first described over a century ago. The structure and function of the centrosome as a …

Adult stem cells play a critical role in tissue repair and maintenance. In tissues with slow
turnover, including skeletal muscle, these cells are maintained in a mitotically quiescent …

Adult muscle tissue largely comprised of differentiated myofibers also harbors quiescent
muscle-resident stem cells (MuSCs) that are responsible for its maintenance, repair and …

Adult stem cells play a critical role in tissue repair and maintenance. In tissues with slow
turnover, including skeletal muscle, these cells are maintained in a mitotically quiescent …

Age is a fundamental aspect of biology that underlies the efficacy of a broad range of
functions. Identifying determinants for how quickly or slowly we age will contribute greatly to …

Muscle stem cells (MuSCs) are essential for the lifelong regeneration and health of skeletal
muscle. In homeostatic conditions the MuSCs exist in a quiescent state but maintain the …

First Person is a series of interviews with the first authors of a selection of papers published
in Journal of Cell Science, helping early-career researchers promote themselves alongside …