Mitochondrial dynamics and mitophagy in skeletal muscle health and aging

JP Leduc-Gaudet, SNA Hussain, E Barreiro… - International journal of …, 2021 - mdpi.com
The maintenance of mitochondrial integrity is critical for muscle health. Mitochondria,
indeed, play vital roles in a wide range of cellular processes, including energy supply, Ca2+ …

The role of mitophagy in skeletal muscle damage and regeneration

E Chatzinikita, M Maridaki, K Palikaras, M Koutsilieris… - Cells, 2023 - mdpi.com
Mitochondria are cellular organelles that play an essential role in generating the chemical
energy needed for the biochemical reactions in cells. Mitochondrial biogenesis, ie, de novo …

Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics

JC Campos, LH Marchesi Bozi… - Proceedings of the …, 2023 - National Acad Sciences
Exercise is a nonpharmacological intervention that improves health during aging and a
valuable tool in the diagnostics of aging-related diseases. In muscle, exercise transiently …

Mitochondrial properties in skeletal muscle fiber

H Dong, SY Tsai - Cells, 2023 - mdpi.com
Mitochondria are the primary source of energy production and are implicated in a wide
range of biological processes in most eukaryotic cells. Skeletal muscle heavily relies on …

Signatures of muscle disuse in spaceflight and bed rest revealed by single muscle fiber proteomics

M Murgia, S Ciciliot, N Nagaraj, C Reggiani… - PNAS …, 2022 - academic.oup.com
Astronauts experience dramatic loss of muscle mass, decreased strength, and insulin
resistance, despite performing daily intense physical exercise that would lead to muscle …

Mitochondrial fusion, fission, and mitophagy in cardiac diseases: challenges and therapeutic opportunities

DL Scheffer, AA Garcia, L Lee… - Antioxidants & Redox …, 2022 - liebertpub.com
Significance: Mitochondria play a critical role in the physiology of the heart by controlling
cardiac metabolism, function, and remodeling. Accumulation of fragmented and damaged …

Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis

V Sidarala, J Zhu, E Levi-D'Ancona, GL Pearson… - Nature …, 2022 - nature.com
Abstract The dynamin-like GTPases Mitofusin 1 and 2 (Mfn1 and Mfn2) are essential for
mitochondrial function, which has been principally attributed to their regulation of …

Mitofusin 2 dysfunction and disease in mice and men

GW Dorn - Frontiers in Physiology, 2020 - frontiersin.org
A causal relationship between Mitofusin (MFN) 2 gene mutations and the hereditary axonal
neuropathy Charcot-Marie-Tooth disease type 2A (CMT2A) was described over 15 years …

Mitochondrial transplantation as a possible therapeutic option for sarcopenia

I Turkel, B Ozerklig, M Yılmaz, O Ulger… - Journal of Molecular …, 2023 - Springer
With advancing age, the skeletal muscle phenotype is characterized by a progressive loss of
mass, strength, and quality. This phenomenon, known as sarcopenia, has a negative impact …

A mitofusin 2/HIF1α axis sets a maturation checkpoint in regenerating skeletal muscle

X Wang, Y Jia, J Zhao, NP Lesner… - The Journal of …, 2022 - Am Soc Clin Investig
A fundamental issue in regenerative medicine is whether there exist endogenous regulatory
mechanisms that limit the speed and efficiency of the repair process. We report the existence …