Amino acids are the building blocks of protein synthesis. They are structural elements and
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …

Methylation of arginine residues by protein arginine methyltransferases (PRMTs) is involved
in the regulation of fundamental cellular processes, including transcription, RNA processing …

Human malignancies arise predominantly in tissues of epithelial origin, where the stepwise
transformation from healthy epithelium to premalignant dysplasia to invasive neoplasia …

Post-translational modification (PTM) of proteins is vital for increasing proteome diversity
and maintaining cellular homeostasis. If the writing, reading, and removal of modifications …

The lineage and developmental trajectory of a cell are key determinants of cellular identity.
In the vascular system, endothelial cells (ECs) of blood and lymphatic vessels differentiate …

The molecular basis of disease progression from UV-induced precancerous actinic keratosis
(AK) to malignant invasive cutaneous squamous cell carcinoma (cSCC) and potentially …

The mammalian target of rapamycin complex1 (mTORC1) is a central regulator of
metabolism and cell growth by sensing diverse environmental signals, including amino …

PRMT1, the major protein arginine methyltransferase in mammals, catalyzes
monomethylation and asymmetric dimethylation of arginine side chains in proteins. Initially …

Casein kinase 1α (CK1α) is a multifunctional protein belonging to the CK1 protein family that
is conserved in eukaryotes from yeast to humans. It regulates signaling pathways related to …

Esophageal squamous cell carcinoma (ESCC) is the most difficult subtype of esophageal
cancer to treat due to a paucity of effective targeted therapy. ESCC is believed to arise from …