Viral-host dependency factors as therapeutic targets to overcome antiviral drug-resistance: a focus on innate immune modulation
The development of antiviral drugs, has provided enormous achievements in our recent
history in the fight against viral infections. To date, most of the approved antiviral drugs target …
history in the fight against viral infections. To date, most of the approved antiviral drugs target …
HibeRNAtion: HIV-1 RNA metabolism and viral latency
HIV-1 infection remains non-curative due to the latent reservoir, primarily a small pool of
resting memory CD4+ T cells bearing replication-competent provirus. Pharmacological …
resting memory CD4+ T cells bearing replication-competent provirus. Pharmacological …
[HTML][HTML] PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency
R Crespo, E Ne, J Reinders, JIJ Meier, C Li, S Jansen… - Iscience, 2024 - cell.com
HIV-1 latency results from tightly regulated molecular processes that act at distinct steps of
HIV-1 gene expression. Here, we characterize PCI domain-containing 2 (PCID2) protein, a …
HIV-1 gene expression. Here, we characterize PCI domain-containing 2 (PCID2) protein, a …
Catchet-MS identifies IKZF1-targeting thalidomide analogues as novel HIV-1 latency reversal agents
A major pharmacological strategy toward HIV cure aims to reverse latency in infected cells
as a first step leading to their elimination. While the unbiased identification of molecular …
as a first step leading to their elimination. While the unbiased identification of molecular …