Objective This collaboration between the American College of Rheumatology and the
American Association of Hip and Knee Surgeons developed an evidence‐based guideline …

Treatment of rheumatoid arthritis (RA) may differ among rheumatologists and currently, clear
and consensual international recommendations on RA treatment are not available. In this …

Objective To compare tumor necrosis factor α inhibitors directly regarding the rates of
treatment response, remission, and the drug survival rate in patients with rheumatoid arthritis …

Background Tumour necrosis factor α (TNFα) inhibitors are frequently used to treat
rheumatoid arthritis, but whether use of a different TNFα inhibitor can improve patient …

Historically, the main classes of drug targets have been receptors, enzymes, ion channels
and transporters. However, owing largely to the rise of antibody-based therapies in the past …

Objective To examine the association of cardiovascular events with tumour necrosis factor
(TNF) α antagonist use compared with non-biological disease-modifying antirheumatic drug …

Objectives To review the evidence for the efficacy and safety of biological agents in patients
with rheumatoid arthritis (RA) to provide data to develop treatment recommendations by the …

Background The biologic disease‐modifying anti‐rheumatic drugs (DMARDs) are very
effective in treating rheumatoid arthritis (RA), however there is a lack of head‐to‐head …

Bone is a dynamic organ constantly remodeled to support calcium homeostasis and
structural needs. The osteoclast is the cell responsible for removing both the organic and …

The NLRP3 inflammasome is activated in response to a variety of signals that are indicative
of damage to the host including tissue damage, metabolic stress, and infection. Upon …