MLL-rearranged leukemias—an update on science and clinical approaches
AC Winters, KM Bernt - Frontiers in pediatrics, 2017 - frontiersin.org
The mixed-lineage leukemia 1 (MLL1) gene (now renamed Lysine [K]-specific
MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of …
MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of …
Structure, function and inhibition of critical protein–protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins
Abstract Mixed lineage leukemia 1 (MLL1, also known as MLL or KMT2A) is an important
transcription factor and histone-H3 lysine-4 (H3K4) methyltransferase. It is a master …
transcription factor and histone-H3 lysine-4 (H3K4) methyltransferase. It is a master …
A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor
S Gadd, V Huff, AL Walz, AHAG Ooms, AE Armstrong… - Nature …, 2017 - nature.com
We performed genome-wide sequencing and analyzed mRNA and miRNA expression, DNA
copy number, and DNA methylation in 117 Wilms tumors, followed by targeted sequencing …
copy number, and DNA methylation in 117 Wilms tumors, followed by targeted sequencing …
Mutant U2AF1 expression alters hematopoiesis and pre-mRNA splicing in vivo
Heterozygous somatic mutations in the spliceosome gene U2AF1 occur in∼ 11% of patients
with myelodysplastic syndromes (MDS), the most common adult myeloid malignancy. It is …
with myelodysplastic syndromes (MDS), the most common adult myeloid malignancy. It is …
A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification
D Mueller, C Bach, D Zeisig… - Blood, The Journal …, 2007 - ashpublications.org
Chimeric proteins joining the histone methyltransferase MLL with various fusion partners
trigger distinctive lymphoid and myeloid leukemias. Here, we immunopurified proteins …
trigger distinctive lymphoid and myeloid leukemias. Here, we immunopurified proteins …
Single cell characterization of myeloma and its precursor conditions reveals transcriptional signatures of early tumorigenesis
Multiple myeloma is a plasma cell malignancy almost always preceded by precursor
conditions, but low tumor burden of these early stages has hindered the study of their …
conditions, but low tumor burden of these early stages has hindered the study of their …
Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype
V Grossmann, E Tiacci, AB Holmes… - Blood, The Journal …, 2011 - ashpublications.org
Among acute myeloid leukemia (AML) patients with a normal karyotype (CN-AML), NPM1
and CEBPA mutations define World Health Organization 2008 provisional entities …
and CEBPA mutations define World Health Organization 2008 provisional entities …
Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets
MD Gearhart, CM Corcoran, JA Wamstad… - … and cellular biology, 2006 - Am Soc Microbiol
The corepressor BCOR potentiates transcriptional repression by the proto-oncoprotein
BCL6 and suppresses the transcriptional activity of a common mixed-lineage leukemia …
BCL6 and suppresses the transcriptional activity of a common mixed-lineage leukemia …
Oculofaciocardiodental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR
D Ng, N Thakker, CM Corcoran, D Donnai, R Perveen… - Nature …, 2004 - nature.com
Lenz microphthalmia is inherited in an X-linked recessive pattern and comprises
microphthalmia, mental retardation, and skeletal and other anomalies. Two loci associated …
microphthalmia, mental retardation, and skeletal and other anomalies. Two loci associated …
YEATS domain proteins: a diverse family with many links to chromatin modification and transcription
JM Schulze, AY Wang, MS Kobor - Biochemistry and Cell …, 2009 - cdnsciencepub.com
Chromatin modifications play crucial roles in various biological processes. An increasing
number of conserved protein domains, often found in multisubunit protein complexes, are …
number of conserved protein domains, often found in multisubunit protein complexes, are …