Synopsis Lamotrigine is an antiepileptic drug which is believed to suppress seizures by
inhibiting the release of excitatory neurotransmitters. Efficacy has been demonstrated for …

Lamotrigine is an antiepileptic agent which blocks voltage-dependent sodium channels,
thereby preventing excitatory neurotransmitter release. Clinical evidence indicates that …

Purpose: To determine whether the toxicity that occurs in some patients when lamotrigine
(LTG) is added to carbamazepine (CBZ) is the result of either a pharmacokinetic or a …

Aims To review (retrospectively) the relationships between lamotrigine (LTG) dosage and
plasma concentrations based on data generated in a routine therapeutic drug monitoring …

Clinical use of the antiepileptic drug (AED) lamotrigine (LTG) has dramatically increased
since its introduction in Europe in 1991 and in the United States in 1994. This article surveys …

Plasma concentrations of lamotrigine, an antiepileptic drug obtained in three adult controlled
clinical trials conducted in the United States were pooled and analyzed using NONMEM, a …

Lamotrigine (LTG) is one of the newer antiepileptic drugs which has been shown to have a
spectrum of drug interactions (including with other epilepsy drugs) that can have a …

Rationale: The relationship between lamotrigine (LTG) serum concentration and clinical
response in patients with epilepsy is still controversial. We therefore performed a …

Purpose: To compare the long‐term retention of gabapentin (GBP), lamotrigine (LTG), and
vigabatrin (VGB) by patients with chronic epilepsy and the reasons for treatment …

Lamotrigine is a novel antiepileptic that, although its mechanism is not completely
understood, appears to affect voltage‐activated sodium channels, resulting in inhibition of …