The immune cells within the tumor microenvironment (TME) play important roles in
tumorigenesis. It has been known that these tumor associated immune cells may possess …

Suppression of antitumor immune responses is one of the main mechanisms by which tumor
cells escape from destruction by the immune system. Myeloid-derived suppressor cells …

Over the last decade, based on the extensive development of preclinical animal studies and
clinical trials, the efficacy, and mechanisms of immunotherapy have been fully explored …

Despite the high long-term survival in localized prostate cancer, metastatic prostate cancer
remains largely incurable even after intensive multimodal therapy. The lethality of advanced …

Immune checkpoint inhibitors (ICI) used for cancer immunotherapy were shown to boost the
existing anti-tumor immune response by preventing the inhibition of T cells by tumor cells …

Despite the promise of immune checkpoint inhibition (ICI), therapeutic responses remain
limited. This raises the possibility that standard of care treatments delivered in concert may …

Abstract Purpose: Natural killer (NK)-cell–based immunotherapy may overcome obstacles to
effective T-cell–based immunotherapy such as the presence of genomic alterations in IFN …

Persistent infection with human papillomavirus (HPV) initiates~ 5% of all human cancers,
and particularly cervical and oropharyngeal cancers. HPV vaccines prevent HPV infection …

Immunotherapies are the most rapidly growing drug class and have a major impact in
oncology and on human health. It is increasingly clear that the effectiveness of …

Recruitment of myeloid-derived suppressor cells (MDSCs) into tumors induces local
immunosuppression in carcinomas. Here, we assessed whether SX-682, an orally …