Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids
RNA–DNA hybrids are generated during transcription, DNA replication and DNA repair and
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …
Walking a tightrope: the complex balancing act of R-loops in genome stability
JR Brickner, JL Garzon, KA Cimprich - Molecular cell, 2022 - cell.com
Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …
R-loop-derived cytoplasmic RNA–DNA hybrids activate an immune response
Abstract R-loops are RNA–DNA-hybrid-containing nucleic acids with important cellular
roles. Deregulation of R-loop dynamics can lead to DNA damage and genome instability …
roles. Deregulation of R-loop dynamics can lead to DNA damage and genome instability …
Regulatory R-loops as facilitators of gene expression and genome stability
C Niehrs, B Luke - Nature reviews Molecular cell biology, 2020 - nature.com
R-loops are three-stranded structures that harbour an RNA–DNA hybrid and frequently form
during transcription. R-loop misregulation is associated with DNA damage, transcription …
during transcription. R-loop misregulation is associated with DNA damage, transcription …
R-loops as cellular regulators and genomic threats
MP Crossley, M Bocek, KA Cimprich - Molecular cell, 2019 - cell.com
During transcription, the nascent RNA strand can base pair with its template DNA, displacing
the non-template strand as ssDNA and forming a structure called an R-loop. R-loops are …
the non-template strand as ssDNA and forming a structure called an R-loop. R-loops are …
Intertwining roles of R-loops and G-quadruplexes in DNA repair, transcription and genome organization
P Wulfridge, K Sarma - Nature Cell Biology, 2024 - nature.com
R-loops are three-stranded nucleic acid structures that are abundant and widespread across
the genome and that have important physiological roles in many nuclear processes. Their …
the genome and that have important physiological roles in many nuclear processes. Their …
TERRA and RAD51AP1 promote alternative lengthening of telomeres through an R-to D-loop switch
Alternative lengthening of telomeres (ALT), a telomerase-independent process maintaining
telomeres, is mediated by break-induced replication (BIR). RAD52 promotes ALT by …
telomeres, is mediated by break-induced replication (BIR). RAD52 promotes ALT by …
S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense
Innate lymphoid cells (ILCs) are innate counterparts of adaptive T lymphocytes, contributing
to host defense, tissue repair, metabolic homeostasis, and inflammatory diseases. ILCs have …
to host defense, tissue repair, metabolic homeostasis, and inflammatory diseases. ILCs have …
FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation
RNA modifications regulate a variety of cellular processes including DNA repair. The RNA
methyltransferase TRDMT1 generates methyl-5-cytosine (m5C) on messenger RNA (mRNA) …
methyltransferase TRDMT1 generates methyl-5-cytosine (m5C) on messenger RNA (mRNA) …
Activation of homologous recombination in G1 preserves centromeric integrity
Centromeric integrity is key for proper chromosome segregation during cell division.
Centromeres have unique chromatin features that are essential for centromere …
Centromeres have unique chromatin features that are essential for centromere …