DNA double-strand breaks (DSBs) arise regularly in cells and when left unrepaired cause
senescence or cell death. Homologous recombination (HR) and nonhomologous end …

Ataxia telangiectasia mutated (ATM) is a central kinase that activates an extensive network
of responses to cellular stress via a signaling role. ATM is activated by DNA double strand …

Most high-grade serous ovarian cancer (HGSOC) patients develop resistance to platinum-
based chemotherapy and recur, but 15% remain disease free over a decade. To discover …

Recent development of innovative tools for live imaging of actin filaments (F-actin) enabled
the detection of surprising nuclear structures responding to various stimuli, challenging …

The repair of DNA double‑strand breaks (DSBs) is crucial for the preservation of genomic
integrity and the maintenance of cellular homeostasis. Non‑homologous DNA end joining …

Cellular senescence is a complex multifactorial biological phenomenon that plays essential
roles in aging, and aging-related diseases. During this process, the senescent cells undergo …

Circular RNAs (circRNAs) are a type of single-stranded RNA molecules forming a covalently
closed, continuous structure, lacking 5′-3′ polarity and polyadenylated tails. Recent …

Eukaryotic nuclei are constantly being exposed to factors that break or chemically modify the
DNA. Accurate repair of this DNA damage is crucial to prevent DNA mutations and maintain …

While it is long known that actin is part of the nuclear proteome, its properties and functions
as regulated, functional and dynamically assembled actin filaments are only recently …

Ataxia-telangiectasia mutated (ATM) is a serine/threonine protein kinase with a master
regulatory function in the DNA damage response. In this role, ATM commands a complex …