Excessive negative regulation of type I interferon disrupts viral control in individuals with Down syndrome

L Malle, M Martin-Fernandez, S Buta, A Richardson… - Immunity, 2022 - cell.com
Down syndrome (DS) is typically caused by triplication of chromosome 21. Phenotypically,
DS presents with developmental, neurocognitive, and immune features. Epidemiologically …

The immune system in Down Syndrome: Autoimmunity and severe infections

M Ramba, D Bogunovic - Immunological Reviews, 2024 - Wiley Online Library
Over 200,000 individuals in the United States alone live with Down Syndrome (DS), the most
common genetic disorder associated with intellectual disability. DS has a constellation of …

Recurrent Respiratory Infections in Children with Down Syndrome: A Review

M Ghezzi, N Garancini, R De Santis, L Gianolio… - Children, 2024 - mdpi.com
Down Syndrome (DS) is the most common chromosomal abnormality compatible with life.
The life of patients suffering from DS can be strongly impacted by Recurrent Respiratory tract …

[HTML][HTML] Down Syndrome in Children: A Primary Immunodeficiency with Immune Dysregulation

A Szczawińska-Popłonyk, N Popłonyk, K Awdi - Children, 2024 - mdpi.com
Background: The multisystemic features of Down syndrome (DS) in children are
accompanied by immunodeficiency, making them susceptible to infections and immune …

SARS-CoV-2 Infection Causes Heightened Disease Severity and Mortality in a Mouse Model of Down Syndrome

RD Pechous, PA Malaviarachchi, Z Xing, A Douglas… - Biomedicines, 2024 - mdpi.com
Recent epidemiological studies suggest that individuals with Down syndrome are more
susceptible to SARS-CoV-2 infection and have higher rates of hospitalization and mortality …

Interferons in Down syndrome: When more is less

LD Notarangelo, M Bosticardo - Immunity, 2022 - cell.com
Individuals with Down syndrome (DS) are at a lower risk for viral infections than the general
population, yet their infectious episodes are often more serious. In this issue of Immunity …

[PDF][PDF] Down Syndrome in Children: An Inborn Error of Immunity with Immune Dysregulation

A Szczawińska-Popłonyk, N Popłonyk, K Awdi - 2024 - preprints.org
Background. The multisystemic features of Down syndrome (DS) in children are
accompanied by an immunodeficiency, making them susceptible to infections and immune …

Investigating Exogenous Stressors Impact on Transcription in Population With Down Syndrome

JVT Huynh-Westfall - 2023 - search.proquest.com
The cell's ability to regulate gene transcription in response to external stimuli is crucial for
proper cell function. Throughout this thesis, I will delve into the intricacies of cellular …

Lower Respiratory Conditions in Down Syndrome

NS Alharbi - The Egyptian Journal of Hospital Medicine, 2022 - journals.ekb.eg
Background: Down syndrome (DS) is by far the most common chromosomal abnormality,
manifested clinically with distinctive dysmorphism, functional and anatomical defects …

HUBUNGAN ANTARA USIA IBU DAN PARITAS DENGAN KEJADIAN SINDROM DOWN

E Zevanya - 2022 - katalog.ukdw.ac.id
Sindrom Down merupakan abnormalitas kromosom yang paling banyak terdiagnosa.
Kejadian sindrom Down meningkat dari tahun ke tahun dan menempati posisi pertama …