Impact of oxygen on pancreatic islet survival

H Komatsu, F Kandeel, Y Mullen - Pancreas, 2018 - journals.lww.com
Pancreatic islet transplantation is a promising treatment option for individuals with type 1
diabetes; however, maintaining islet function after transplantation remains a large challenge …

[HTML][HTML] Posttransplant oxygen inhalation improves the outcome of subcutaneous islet transplantation: a promising clinical alternative to the conventional intrahepatic …

H Komatsu, J Rawson, A Barriga, N Gonzalez… - American Journal of …, 2018 - Elsevier
Subcutaneous tissue is a promising site for islet transplantation, due to its large area and
accessibility, which allows minimally invasive procedures for transplantation, graft …

An intrinsically semi-permeable PDMS nanosheet encapsulating adipose tissue-derived stem cells for enhanced angiogenesis

M Takuma, H Fujita, N Zushi, H Nagano… - Biomaterials …, 2024 - pubs.rsc.org
Cell encapsulation devices are expected to be promising tools that can control the release of
therapeutic proteins secreted from transplanted cells. The protein permeability of the device …

Characterization of human islet function in a convection‐driven intravascular bioartificial pancreas

AG Santandreu, P Taheri‐Tehrani… - Bioengineering & …, 2023 - Wiley Online Library
Clinical islet transplantation for treatment of type 1 diabetes (T1D) is limited by the shortage
of pancreas donors and need for lifelong immunosuppressive therapy. A convection‐driven …

Oxygen transporter for the hypoxic transplantation site

H Komatsu, CA Cook, N Gonzalez, L Medrano… - …, 2018 - iopscience.iop.org
Cell transplantation is a promising treatment for complementing lost function by replacing
new cells with a desired function, eg pancreatic islet transplantation for diabetics. To prevent …

Isolated pancreatic islet yield and quality is inversely related to organ donor age in rats

N Gonzalez, M Salgado, L Medrano, Y Mullen… - Experimental …, 2019 - Elsevier
Pancreatic islets consist of several endocrine cell types that maintain glucose homeostasis.
Type 1 diabetes (T1D) results from autoimmune-mediated destruction of insulin producing …

MEMS Silicon Cutters for Rapid Sectioning of Diffusion-Limited Pancreatic Islets to Improve Viability

C Cook, H Komatsu, M Salgado… - … Conference on Solid …, 2019 - ieeexplore.ieee.org
This paper reports on the first MEMS silicon cutters designed to rapidly section donor
pancreatic islets below oxygen diffusion-limited dimensions to improve viability of grafts …