Respiratory syncytial virus entry and how to block it

MB Battles, JS McLellan - Nature Reviews Microbiology, 2019 - nature.com
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease in
young children and elderly people. Although the virus was isolated in 1955, an effective …

[HTML][HTML] Viral membrane fusion

SC Harrison - Virology, 2015 - Elsevier
Membrane fusion is an essential step when enveloped viruses enter cells. Lipid bilayer
fusion requires catalysis to overcome a high kinetic barrier; viral fusion proteins are the …

Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion

AC Walls, MA Tortorici, J Snijder… - Proceedings of the …, 2017 - National Acad Sciences
The tremendous pandemic potential of coronaviruses was demonstrated twice in the past
few decades by two global outbreaks of deadly pneumonia. The coronavirus spike (S) …

Nano-based approach to combat emerging viral (NIPAH virus) infection

RG Kerry, S Malik, YT Redda, S Sahoo, JK Patra… - … , Biology and Medicine, 2019 - Elsevier
Emergence of new virus and their heterogeneity are growing at an alarming rate. Sudden
outburst of Nipah virus (NiV) has raised serious question about their instant management …

Architecture and antigenicity of the Nipah virus attachment glycoprotein

Z Wang - Biophysical Journal, 2022 - cell.com
Nipah virus (NiV) and Hendra virus (HeV) are highly pathogenic zoonotic henipaviruses
(HNVs) responsible for recurrent outbreaks of encephalitis and respiratory illness. As the …

Virus and cell fusion mechanisms

B Podbilewicz - Annual review of cell and developmental …, 2014 - annualreviews.org
In biomembrane fusion pathways, membranes are destabilized through insertions of
amphipathic protein segments, lipid reorganization via hemifusion, protein restructuring, and …

The immunobiology of Nipah virus

YJM Liew, PAS Ibrahim, HM Ong, CN Chong, CT Tan… - Microorganisms, 2022 - mdpi.com
Nipah virus (NiV) is a highly lethal zoonotic paramyxovirus that emerged in Malaysia in
1998. It is a human pathogen capable of causing severe respiratory infection and …

Activation of paramyxovirus membrane fusion and virus entry

TS Jardetzky, RA Lamb - Current opinion in virology, 2014 - Elsevier
Highlights•Most paramyxoviruses require attachment and fusion (F) proteins for cell
entry.•Competing 'clamp'and 'provocateur'models have been proposed as entry …

Broadly neutralizing antibody cocktails targeting Nipah virus and Hendra virus fusion glycoproteins

HV Dang, RW Cross, V Borisevich… - Nature Structural & …, 2021 - nature.com
Abstract Hendra virus (HeV) and Nipah virus (NiV) are henipaviruses (HNVs) causing
respiratory illness and severe encephalitis in humans, with fatality rates of 50–100%. There …

Measles virus fusion protein: structure, function and inhibition

P Plattet, L Alves, M Herren, HC Aguilar - Viruses, 2016 - mdpi.com
Measles virus (MeV), a highly contagious member of the Paramyxoviridae family, causes
measles in humans. The Paramyxoviridae family of negative single-stranded enveloped …