Determining how chromosomes are positioned and folded within the nucleus is critical to
understanding the role of chromatin topology in gene regulation. Several methods are …

Over a decade ago the advent of high-throughput chromosome conformation capture (Hi-C)
sparked a new era of 3D genomics. Since then the number of methods for mapping the 3D …

Osteoporosis is a common aging-related disease diagnosed primarily using bone mineral
density (BMD). We assessed genetic determinants of BMD as estimated by heel quantitative …

Over the past decade, 3C-related methods have provided remarkable insights into
chromosome folding in vivo. To overcome the limited resolution of prior studies, we extend a …

Chromosome conformation capture (3C) assays are used to map chromatin interactions
genome-wide. Chromatin interaction maps provide insights into the spatial organization of …

Xist represents a paradigm for the function of long non-coding RNA in epigenetic regulation,
although how it mediates X-chromosome inactivation (XCI) remains largely unexplained …

Skates are cartilaginous fish whose body plan features enlarged wing-like pectoral fins,
enabling them to thrive in benthic environments,. However, the molecular underpinnings of …

The ring-like cohesin complex mediates sister-chromatid cohesion by encircling pairs of
sister chromatids. Cohesin also extrudes loops along chromatids. Whether the two activities …

Nuclear compartmentalization of active and inactive chromatin is thought to occur through
microphase separation mediated by interactions between loci of similar type. The nature and …

Many evolutionarily distant pathogenic organisms have evolved similar survival strategies to
evade the immune responses of their hosts. These include antigenic variation, through …