Induction of endogenous antimicrobial peptides to prevent or treat oral infection and inflammation

KA Morio, RH Sternowski, KA Brogden - Antibiotics, 2023 - mdpi.com
Antibiotics are often used to treat oral infections. Unfortunately, excessive antibiotic use can
adversely alter oral microbiomes and promote the development of antibiotic-resistant …

[HTML][HTML] Nutritional Modulation of Host Defense Peptide Synthesis: A Novel Host-Directed Antimicrobial Therapeutic Strategy?

M Whitmore, I Tobin, A Burkardt, G Zhang - Advances in Nutrition, 2024 - Elsevier
The escalating threat of antimicrobial resistance underscores the imperative for innovative
therapeutic strategies. Host defense peptides (HDPs), integral components of innate …

The Endogenous Retinoic Acid Receptor Pathway Is Exploited by Mycobacterium tuberculosis during Infection, Both In Vitro and In Vivo

YK Tenório de Menezes, C Eto… - The Journal of …, 2023 - journals.aai.org
Retinoic acid (RA) is a fundamental vitamin A metabolite involved in regulating immune
responses through the nuclear RA receptor (RAR) and retinoid X receptor. While performing …

[HTML][HTML] Microfluidics produced ATRA-loaded PLGA NPs reduced tuberculosis burden in alveolar epithelial cells and enabled high delivered dose under simulated …

AZ Bahlool, B Cavanagh, A O'Sullivan… - European Journal of …, 2024 - Elsevier
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is second only to COVID-19 as
the top infectious disease killer worldwide. Multi-drug resistant TB (MDR-TB) may arise …

ERK1/2-CEBPB Axis-Regulated hBD1 Enhances Anti-Tuberculosis Capacity in Alveolar Type II Epithelial Cells

Y Chen, Z Han, S Zhang, H Liu, K Wang, J Liu… - International Journal of …, 2024 - mdpi.com
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a global health crisis
with substantial morbidity and mortality rates. Type II alveolar epithelial cells (AEC-II) play a …

The role of cathelicidins in neutrophil biology

G Yoon, R Puentes, J Tran, A Multani… - Journal of Leukocyte …, 2024 - academic.oup.com
Despite their relatively short lifespan, neutrophils are tasked with counteracting pathogens
through various functions, including phagocytosis, production of r eactive o xygen s pecies …

¿ Los neutrófilos como células de defensa? Inmunobiología y fisiopatología en las enfermedades infecciosas respiratorias humanas

EU Rojas-Valles, CA Magaña-González… - NCT Neumología y …, 2024 - medigraphic.com
El sistema inmunológico nos protege de las infecciones y la entrada de cualquier patógeno
activa la inmunidad innata. Los neutrófilos son parte de este tipo de respuesta y son los más …

Improving retinoic acid efficacy: lipase‐catalyzed synthesis of derivatives with antiviral activity

G Garcia Linares, SC Bravo, CA Montalbetti… - ChemBioChem - Wiley Online Library
An efficient enzymatic approach was applied to the synthesis of new derivatives of retinoic
acid. Nine derivatives, four of them new compounds, were obtained through lipase‐catalysis …

Tuberculosis: análisis de la historia y generación de múltiple resistencia a antibióticos.

YM Jacobo-Delgado, D Jesús-González… - … Medica del IMSS, 2024 - search.ebscohost.com
Tuberculosis is an ancient disease that has accompanied humanity for the last three
thousand years and is considered the oldest infectious disease that still exists. The …

[PDF][PDF] Neutrophils as defense cells? Immunobiology and pathophysiology in human respiratory infectious diseases

EU Rojas-Valles, CA Magaña-González… - Neumol Cir …, 2023 - medigraphic.com
The immune system protects us from infections and the entry of any pathogen activates
innate immunity. Neutrophils are part of this type of response and are the most abundant in …