Base excision repair in the immune system: small DNA lesions with big consequences
M Stratigopoulou, TP van Dam… - Frontiers in …, 2020 - frontiersin.org
The integrity of the genome is under constant threat of environmental and endogenous
agents that cause DNA damage. Endogenous damage is particularly pervasive, occurring at …
agents that cause DNA damage. Endogenous damage is particularly pervasive, occurring at …
The base excision repair process: comparison between higher and lower eukaryotes
The base excision repair (BER) pathway is essential for maintaining the stability of DNA in
all organisms and defects in this process are associated with life-threatening diseases. It is …
all organisms and defects in this process are associated with life-threatening diseases. It is …
[HTML][HTML] Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer
TMA Abdel-Fatah, R Russell, N Albarakati… - Molecular …, 2014 - Elsevier
FEN1 has key roles in Okazaki fragment maturation during replication, long patch base
excision repair, rescue of stalled replication forks, maintenance of telomere stability and …
excision repair, rescue of stalled replication forks, maintenance of telomere stability and …
Functional mutation, splice, distribution, and divergence analysis of impactful genes associated with heart failure and other cardiovascular diseases
I Mhatre, H Abdelhalim, W Degroat, S Ashok… - Scientific reports, 2023 - nature.com
Cardiovascular disease (CVD) is caused by a multitude of complex and largely heritable
conditions. Identifying key genes and understanding their susceptibility to CVD in the human …
conditions. Identifying key genes and understanding their susceptibility to CVD in the human …
[HTML][HTML] Untangling the ATR-CHEK1 network for prognostication, prediction and therapeutic target validation in breast cancer
ATR-CHEK1 signalling is critical for genomic stability. ATR-CHEK1 signalling may be
deregulated in breast cancer and have prognostic, predictive and therapeutic significance …
deregulated in breast cancer and have prognostic, predictive and therapeutic significance …
[HTML][HTML] Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy
N Albarakati, TMA Abdel-Fatah, R Doherty, R Russell… - Molecular …, 2015 - Elsevier
BRCA1, a key factor in homologous recombination (HR) repair may also regulate base
excision repair (BER). Targeting BRCA1-BER deficient cells by blockade of ATM and DNA …
excision repair (BER). Targeting BRCA1-BER deficient cells by blockade of ATM and DNA …
Transcriptionally amplified synthesis of fluorogenic RNA aptamers for label-free DNA glycosylase assay
We demonstrate for the first time the utilization of fluorogenic RNA aptamers for label-free
uracil-DNA glycosylase (UDG) assay. Through rationally engineering the transcription …
uracil-DNA glycosylase (UDG) assay. Through rationally engineering the transcription …
A regulatory network comprising let-7 miRNA and SMUG1 is associated with good prognosis in ER+ breast tumours
L Lirussi, D Ayyildiz, Y Liu, NP Montaldo… - Nucleic Acids …, 2022 - academic.oup.com
Single-strand selective uracil–DNA glycosylase 1 (SMUG1) initiates base excision repair
(BER) of uracil and oxidized pyrimidines. SMUG1 status has been associated with cancer …
(BER) of uracil and oxidized pyrimidines. SMUG1 status has been associated with cancer …
Transcriptomic and protein expression analysis reveals clinicopathological significance of bloom syndrome helicase (BLM) in breast cancer
Bloom syndrome helicase (BLM) has key roles in homologous recombination repair,
telomere maintenance, and DNA replication. Germ-line mutations in the BLM gene causes …
telomere maintenance, and DNA replication. Germ-line mutations in the BLM gene causes …
Unravelling the clinicopathological and functional significance of replication protein A (RPA) heterotrimeric complex in breast cancers
M Algethami, MS Toss, CL Woodcock, C Jaipal… - NPJ Breast …, 2023 - nature.com
Abstract Replication Protein A (RPA), a heterotrimeric complex consisting of RPA1, 2, and 3
subunits, is a single-stranded DNA (ssDNA)-binding protein that is critically involved in …
subunits, is a single-stranded DNA (ssDNA)-binding protein that is critically involved in …