Skeletal infections: microbial pathogenesis, immunity and clinical management

EA Masters, BF Ricciardi, KLM Bentley… - Nature Reviews …, 2022 - nature.com
Osteomyelitis remains one of the greatest risks in orthopaedic surgery. Although many
organisms are linked to skeletal infections, Staphylococcus aureus remains the most …

Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”,“the immune proteome” and “local antibiotic therapy”

EA Masters, RP Trombetta, KL de Mesy Bentley… - Bone research, 2019 - nature.com
Osteomyelitis is a devastating disease caused by microbial infection of bone. While the
frequency of infection following elective orthopedic surgery is low, rates of reinfection are …

[HTML][HTML] Antibacterial effect of 3D printed mesoporous bioactive glass scaffolds doped with metallic silver nanoparticles

S Sánchez-Salcedo, A García, A González-Jiménez… - Acta Biomaterialia, 2023 - Elsevier
The development of new biomaterials for bone tissue regeneration with high bioactivity
abilities and antibacterial properties is being intensively investigated. We have synthesized …

2018 international consensus meeting on musculoskeletal infection: research priorities from the general assembly questions

EM Schwarz, J Parvizi, T Gehrke, A Aiyer… - Journal of …, 2019 - Wiley Online Library
Musculoskeletal infections (MSKI) remain the bane of orthopedic surgery, and result in
grievous illness and inordinate costs that threaten healthcare systems. As prevention …

How microbes read the map: Effects of implant topography on bacterial adhesion and biofilm formation

SW Lee, KS Phillips, H Gu, M Kazemzadeh-Narbat… - Biomaterials, 2021 - Elsevier
Microbes have remarkable capabilities to attach to the surface of implanted medical devices
and form biofilms that adversely impact device function and increase the risk of multidrug …

Staphylococcus aureus osteomyelitis: bone, bugs, and surgery

KL Urish, JE Cassat - Infection and immunity, 2020 - Am Soc Microbiol
Osteomyelitis, or inflammation of bone, is most commonly caused by invasion of bacterial
pathogens into the skeleton. Bacterial osteomyelitis is notoriously difficult to treat, in part …

Biomaterials against bone infection

M Vallet‐Regí, D Lozano, B González… - Advanced …, 2020 - Wiley Online Library
Chronic bone infection is considered as one of the most problematic biofilm‐related
infections. Its recurrent and resistant nature, high morbidity, prolonged hospitalization, and …

The current knowledge on the pathogenesis of tissue and medical device-related biofilm infections

EG Di Domenico, A Oliva, M Guembe - Microorganisms, 2022 - mdpi.com
Biofilm is the trigger for the majority of infections caused by the ability of microorganisms to
adhere to tissues and medical devices. Microbial cells embedded in the biofilm matrix are …

Mechanisms of Immune Evasion and Bone Tissue Colonization That Make Staphylococcus aureus the Primary Pathogen in Osteomyelitis

G Muthukrishnan, EA Masters, JL Daiss… - Current osteoporosis …, 2019 - Springer
Abstract Purpose of Review Staphylococcus aureus is the primary pathogen responsible for
osteomyelitis, which remains a major healthcare burden. To understand its dominance, here …

Osteoarticular mycoses

MN Gamaletsou, B Rammaert, B Brause… - Clinical Microbiology …, 2022 - Am Soc Microbiol
Osteoarticular mycoses are chronic debilitating infections that require extended courses of
antifungal therapy and may warrant expert surgical intervention. As there has been no …