Plants belonging to the Amaryllidaceae family are well known for their ornamental and
medicinal use. Plant members of this group are distributed through both tropical and …

In the past two decades, substantial advances have been made on the asymmetric alkyne
functionalization by the activation of inert alkynes. However, these asymmetric …

The title alkaloids, often referred to collectively as crinines, are a prominent group of
structurally distinct natural products with additional members being reported on a regular …

Alkaloids isolated from members of the Amaryllidaceae plant family are promising
anticancer agents. The purpose of the current study was to determine if the isocarbostyrils …

Background Lycorine has been revealed to inhibit the development of many kinds of
malignant tumors, including glioblastoma multiforme (GBM). Although compelling evidences …

Pancreatic cancer is highly metastatic and lethal with an increasing incidence globally and a
5-year survival rate of only 8%. One of the factors contributing to the high mortality is the lack …

Highly pathogenic H5N1 influenza viruses (HPAIV) cause rapid systemic illness and death
in susceptible animals, leading to a disease with high morbidity and mortality rates. Although …

Alzheimer's disease (AD) is a multifactorial neurodegenerative condition of the central
nervous system (CNS) that is currently treated by cholinesterase inhibitors and the N-methyl …

Metastatic melanoma accounts for 60% of death for skin cancer. Although great efforts have
been made to treat the disease, effective drugs against metastatic melanoma still lack at the …

Functionalized hydroindole (1), a common chiral synthon, for versatile transformations to
synthesize a broad range of Amaryllidaceae alkaloids (AAs) including (−)-crinine,(−) …