Synthetic systems powered by biological molecular motors

G Saper, H Hess - Chemical reviews, 2019 - ACS Publications
Biological molecular motors (or biomolecular motors for short) are nature's solution to the
efficient conversion of chemical energy to mechanical movement. In biological systems …

Engineering strategies for sustainable synthetic cells

X Wang, S Wu, TYD Tang, L Tian - Trends in Chemistry, 2022 - cell.com
An ongoing grand challenge in bottom-up synthetic biology is designing and constructing
synthetic cells with life-like properties. Despite the significant advances, even the most …

Enzyme-powered motility in buoyant organoclay/DNA protocells

BP Kumar, AJ Patil, S Mann - Nature chemistry, 2018 - nature.com
Reconstitution and simulation of cellular motility in microcompartmentalized colloidal objects
have important implications for microcapsule-based remote sensing, environmentally …

Memoryless self-reinforcing directionality in endosomal active transport within living cells

K Chen, B Wang, S Granick - Nature Materials, 2015 - nature.com
In contrast to Brownian transport, the active motility of microbes, cells, animals and even
humans often follows another random process known as truncated Lévy walk,. These …

Kinesin-1-transported liposomes prefer to go straight in 3D microtubule intersections by a mechanism shared by other molecular motors

BM Bensel, SB Previs, C Bookwalter, KM Trybus… - Proceedings of the …, 2024 - pnas.org
Kinesin-1 ensembles maneuver vesicular cargoes through the three-dimensional (3D)
intracellular microtubule (MT) network. To define how such cargoes navigate MT …

Transport efficiency of membrane-anchored kinesin-1 motors depends on motor density and diffusivity

R Grover, J Fischer, FW Schwarz… - Proceedings of the …, 2016 - National Acad Sciences
In eukaryotic cells, membranous vesicles and organelles are transported by ensembles of
motor proteins. These motors, such as kinesin-1, have been well characterized in vitro as …

All wired up: an exploration of the electrical properties of microtubules and tubulin

AP Kalra, BB Eakins, SD Patel, G Ciniero, V Rezania… - ACS …, 2020 - ACS Publications
Microtubules are hollow, cylindrical polymers of the protein α, β tubulin, that interact
mechanochemically with a variety of macromolecules. Due to their mechanically robust …

Cholesterol in the cargo membrane amplifies tau inhibition of kinesin-1-based transport

Q Li, JT Ferrare, J Silver, JO Wilson… - Proceedings of the …, 2023 - National Acad Sciences
Intracellular cargos are often membrane-enclosed and transported by microtubule-based
motors in the presence of microtubule-associated proteins (MAPs). Whereas increasing …

Motor coupling through lipid membranes enhances transport velocities for ensembles of myosin Va

SR Nelson, KM Trybus… - Proceedings of the …, 2014 - National Acad Sciences
Myosin Va is an actin-based molecular motor responsible for transport and positioning of a
wide array of intracellular cargoes. Although myosin Va motors have been well …

Investigation of the electrical properties of microtubule ensembles under cell-like conditions

AP Kalra, SD Patel, AF Bhuiyan, J Preto, KG Scheuer… - Nanomaterials, 2020 - mdpi.com
Microtubules are hollow cylindrical polymers composed of the highly negatively-charged (~
23e), high dipole moment (1750 D) protein α, β-tubulin. While the roles of microtubules in …